Synthesis, Antimicrobial and Antibiofilm Activities, and Molecular Docking Investigations of 2-(1-Indol-3-yl)-1-benzo[]imidazole Derivatives.

The treatment of many bacterial and fungal infections remains a problem due to increasing antibiotic resistance and biofilm formation by pathogens. In the present article, a methodology for the chemoselective synthesis of 2-(1-indol-3-yl)-1-benzo[]imidazole derivatives is presented. We report on the antimicrobial activity of synthesized 2-(1-indol-3-yl)-1-benzo[]imidazoles with significant activity against ATCC 25923, ATCC 43300 (MRSA), (mc(2)155/ATCC 700084), and ATCC 10231.

The Synthesis and Biological Evaluation of 2-(1-Indol-3-yl)quinazolin-4(3)-One Derivatives.

The treatment of many bacterial diseases remains a significant problem due to the increasing antibiotic resistance of their infectious agents. Among others, this is related to , especially methicillin-resistant (MRSA) and . In the present article, we report on antibacterial compounds with activity against both and MRSA.

Extended Version of the Corey-Chaykovsky Reaction: Synthesis of 2,4-Substituted Furans by the Treatment of β-Dialkylamino Chalcones with Dimethylsulfonium Methylide.

We describe the synthesis of functionalized furans using the concept of the extended Corey-Chaykovsky reaction. Namely, β,β-disubstituted α,β-unsaturated ketones were treated with dimethylsulfonium methylide to give vinyloxiranes, which immediately rearranged into the corresponding furans. The developed approach allows for synthesizing a broad range of unsymmetrically di- and trisubstituted furans containing various functionalities in the core.

Transformation of 3-(Furan-2-yl)-1,3-di(het)arylpropan-1-ones to Prop-2-en-1-ones via Oxidative Furan Dearomatization/2-Ene-1,4,7-triones Cyclization.

The approach to 3-(furan-2-yl)-1,3-di(het)arylprop-2-en-1-ones based on the oxidative dearomatization of 3-(furan-2-yl)-1,3-di(het)arylpropan-1-ones followed by an unusual cyclization of the formed di(het)aryl-substituted 2-ene-1,4,7-triones has been developed. The cyclization step is related to the Paal-Knorr synthesis, but the furan ring formation is accompanied in this case by a formal shift of the double bond through the formation of a fully conjugated 4,7-hydroxy-2,4,6-trien-1-one system or its surrogate.