Publications by authors named "Roman Macaya"
A striking feature of COVID-19 disease is the broad spectrum of risk factors associated with case severity, as well as the diversity of clinical manifestations. While no central agent has been able to explain the pathogenesis of SARS-CoV-2 infection, the factors that most robustly correlate with severity are risk factors linked to aging. Low serum levels of Klotho, an anti-aging protein, strongly correlate with the pathogenesis of the same risk factors and manifestations of conditions similar to those expressed in severe COVID-19 cases.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2 variants are less effectively neutralized by vaccines and monoclonal antibodies, necessitating alternative treatments.
- Researchers tested therapeutic equine polyclonal antibodies against five significant variants (alpha, beta, epsilon, gamma, delta) and found they efficiently neutralized these variants at very low concentrations.
- Equine polyclonal antibodies offer a promising treatment option due to their effectiveness, broad coverage, low cost, and scalability for COVID-19.