Synopsis of recent research by authors named "Roman Kulikov"
- Roman Kulikov's research primarily investigates the regulatory mechanisms governing the p53 tumor suppressor protein, focusing on its interactions with Mdm2, a key ubiquitin ligase that targets p53 for degradation.
- His findings reveal that Mdm2 not only facilitates the ubiquitination of p53 but also has critical post-ubiquitylation roles in promoting p53's association with the proteasome, highlighting the complexity of p53 regulation.
- Additionally, Kulikov's work demonstrates the importance of phosphorylation events in modulating Mdm2's function, which subsequently impacts the stability and activity of p53 in response to cellular stress signals, such as DNA damage.
