Antimicrobial Zn-Carboxymethyl Chitosan Cryogel for Controlled Loading and Release of Ciprofloxacin via Coordination Bonds.

The local application of broad-spectrum antibiotics via polymeric drug delivery systems is a promising alternative to their systemic administration in wound healing, prevention and treatment of infections associated with surgical implants. However, low and poorly controlled loading efficiency and 100% burst release are common problems for the materials with weak physical interaction between antibiotics and polymeric matrices. Here, we report a new multifunctional carboxymethyl chitosan (CMC) cryogel, which efficiently prevents bacterial adhesion to the surface, kills bacteria in the solution via controlled release of ciprofloxacin (CIP), and promotes fibroblast proliferation.

Indices of nonspecific bronchial reactivity in severe asthma phenotype determination in schoolchildren.

Objective: Introduction: Severe asthma phenotype is characterized by peculiarities of inflammatory process in the airways and consequently hypersensitivity and bronchial lability. The aim: The study aims at determining the diagnostic value of bronchial lability indices in identifying severe bronchial asthma phenotype compared to the moderate variant of disease in schoolchildren.

Patients And Methods: Materials and methods: We formed two clinical groups of observation, the first clinical group included 57 children with severe asthma phenotype, the second clinical group included 65 patients with moderate disease course.