Publications by authors named "Roman G Zenkov"
Article Synopsis
- Guanine-rich DNA sequences in oncogene promoters often form G-quadruplex (G4) structures, which can be stabilized by specific ligands, affecting gene expression.
- The study investigated how various plant secondary metabolites (PSMs) interact with G4s and influence gene expression in cells using methods like fluorescent assays and spectroscopy.
- Findings revealed that several PSMs, including sanguinarine and quercetin, can downregulate gene expression via direct interactions with G4s and also through indirect effects on cell signaling pathways.
Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo. We studied the mechanisms of anticancer activity in accordance with the previously described effects of indolocarbazoles.
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