Publications by authors named "Roman Abrosimov"
Low-molecular-mass organic chemicals are widely discussed as potential indicators of life in extraterrestrial habitats. However, demarcation lines between biotic chemicals and abiotic chemicals have been difficult to define. Here, we have analyzed the potential utility of the quantum chemical property, HOMO-LUMO gap (HLG), as a novel proxy variable of life, since a significant trend towards incrementally smaller HLGs has been described in the genetically encoded amino acids.
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- - Metformin and certain natural toxins primarily exert their antidiabetic effects by inhibiting mitochondrial complex I (NADH dehydrogenase), which also occurs through methods like antidiabetic PPAR agonists and methionine restriction.
- - An analysis of various studies revealed that, despite mitochondrial impairment, pathways for NADPH formation and fatty acid synthesis are activated alongside catabolic processes, creating a "futile" cycle that consumes energy without producing useful NADH.
- - This complex I inhibition leads to a metabolic shift towards the pentose phosphate pathway for NADPH production, fostering a diabetes-resistant phenotype by altering fat metabolism and signaling pathways to remodel adipose tissue for glucose utilization.
Lipid peroxidation is a biochemically adverse phenomenon with key involvement in many different diseases including premature infant blindness, nonalcoholic steatohepatitis, or Parkinson's disease. Moreover, lipid peroxidation may be the most important universal driver of the biological aging process. Canonic lipid peroxidation is a free radical chain reaction consisting of three kinetically independent steps, initiation, propagation, and termination.
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