The preparation, characterisation and in vitro cytotoxicity of potentially chemotherapeutic heterobimetallic complexes containing early and late transition metals.

The reactions of phosphine Ph(2)P(CH(2))(2)SO(3)Na with Cp(2)M'Cl(2) (M'=Ti, Zr) in aqueous solution give the metallophosphines, Cp(2)Ti(OSO(2)(CH(2))(2)PPh(2))(2) (Cp=cyclopentadienyl) and CpZr(OH)(OSO(2)(CH(2))(2)PPh(2))(2). These react with CODM"Cl(2) (M"=Pd, Pt) (COD=1,5-cyclooctadiene) in dichloromethane to give heterobimetallic complexes Cp(2)Ti(OSO(2)(CH(2))(2)PPh(2))(2)M"Cl(2) and CpZr(OH)(OSO(2)(CH(2))(2) PPh(2))(2)M"Cl(2) respectively. The compounds are characterised by infrared and NMR spectroscopies and elemental analysis.

Conformational Analysis of 2-Substituted Alkylphosphoryl Compounds. 4. Substituent Effect on the Nature of the Hydrogen Bonding in (2-Hydroxyalkyl)phosphoryl Systems.

The extent to which solid state conformational and hydrogen bonding preferences of five (2-hydroxyalkyl)phosphoryl compounds 2a-e [R(1)(2)P(O)CH(2)CH(OH)R(2); 2a, R(1) = MeO, R(2) = Ph; 2b, R(1) = R(2) = Ph; 2c, R(1) = Ph, R(2) = Bu(t); 2d, R(1) = Me, R(2) = Ph; 2e, R(1) = Me, R(2) = Bu(t)] change upon dissolution has been investigated using X-ray crystallography, IR, and NMR spectroscopy. Intermolecular hydrogen bonding involving inversion-center-related cyclic dimers is shown to be a common solid state arrangement, with relatively small structural changes producing infinite chains. Intramolecular hydrogen bonded monomers are uncommon.