A new methodology to predict the oncotype scores based on clinico-pathological data with similar tumor profiles.

Purpose: The Oncotype DX (ODX) test is a commercially available molecular test for breast cancer assay that provides prognostic and predictive breast cancer recurrence information for hormone positive, HER2-negative patients. The aim of this study is to propose a novel methodology to assist physicians in their decision-making.

Methods: A retrospective study between 2012 and 2020 with 333 cases that underwent an ODX assay from three hospitals in the Bourgogne Franche-Comté region (France) was conducted.

Evaporation-Driven Cellular Patterns in Confined Hyperelastic Hydrogels.

When a hyperelastic hydrogel confined between two parallel glass plates begins to dry from a lateral boundary, the volume lost by evaporation is accommodated by an inward displacement of the air-hydrogel interface that induces an elastic deformation of the hydrogel. Once a critical front displacement is reached, we observe intermittent fracture events initiated by a geometric instability resulting in localized bursts at the interface. These bursts relax the stresses and irreversibly form air cavities that lead to cellular networks.