Phenotyping transgenic embryonic murine hearts using optical coherence tomography.

We used optical coherence tomography (OCT) to characterize the morphological phenotype of embryonic murine hearts discerning hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) mutants from their wild-type littermates. At E12.5 and E13.

Imaging of iris lesions with high-speed optical coherence tomography.

Background And Objectives: To image and measure iris tumors with optical coherence tomography (OCT).

Patients And Methods: High-speed (2,000-4,000 axial-scan/sec and 4-16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma.

Theory of two beam interference with arbitrary spectra.

A new formulation describing the interference term of a two beam interferometer with unequal Gaussian spectra propagating in different dispersive media is provided by defining a composite standard deviation and a composite center frequency of the interfering spectra. This formulation is generalized to arbitrary spectra by decomposing each spectrum into a linear composition of Gaussian distributions. The effective phase and group delays indicate the effect of the unequal spectral distributions and the dispersive media.

Integrated residential treatment for persons with severe and persistent mental illness: lessons in recovery.

This retrospective study examines 24-month outcomes for 38 participants with histories of chronic homelessness and hospitalizations in an urban, residential integrated treatment (IT) program and compares characteristics of those who stayed in the program 24 months with those who left within their first year of residence. Informed by an Assertive Community Treatment approach, characterized by outreach (or what might better be referred to as inreach), low staff to consumer ratio, and meeting of basic needs, the residential program emphasized harm reduction and motivational interventions. The longitudinal study design was supplemented with a comparative analysis of treatment completers and noncompleters.

Comparison of corneal thickness measured with optical coherence tomography, ultrasonic pachymetry, and a scanning slit method.

Purpose: To investigate the relationship between 1310-nm optical coherence tomography (OCT), an ultrasound pachymeter, and the Orbscan II (Bausch & Lomb, Rochester, NY) in corneal thickness measurements before and after LASIK.

Methods: Twenty-eight eyes of 14 patients with a mean age of 39.9 +/- 8.

Computer-aided diagnosis of dysplasia in Barrett's esophagus using endoscopic optical coherence tomography.

Barrett's esophagus (BE) and associated adenocarcinoma have emerged as a major health care problem over the last two decades. Because of the widespread use of endoscopy, BE is being recognized increasingly in all Western countries. In clinical trials of endoscopic optical coherence tomography (EOCT), we defined certain image features that appear to be characteristic of precancerous (dysplastic) mucosa: decreased scattering and disorganization in the microscopic morphology.

A feasibility study of optical coherence tomography for guiding deep brain probes.

Deep brain simulation (DBS) is effective for the treatment of various diseases including Parkinson's disease and essential tremor. However, anatomical targeting combined with microelectrode mapping of the region requires significant surgical time. Also, the fine-tipped microelectrode imposes a risk of hemorrhage in the event that the trajectory intersects subcortical vessels.

Literacy and perceived barriers to medication taking among homeless mothers and their children.

Purpose: The relation of medical literacy to women-reported barriers to taking medication themselves or giving medication to their children was studied.

Methods: Women in 18 homeless shelters in four counties in central North Carolina were recruited. Head-of-household homeless mothers with psychiatric or substance-abuse disorders and dependent children were eligible to participate.

Racial differences in the use of antidepressants and counseling for depression among homeless women.

The purpose of the current study was to examine how African American race was related to the use of antidepressants and counseling among homeless depressed women. Women were recruited in 18 homeless shelters in four counties in central North Carolina. Head of household homeless mothers with psychiatric and/or substance abuse disorders who had dependent children were eligible to participate.

4D embryonic cardiography using gated optical coherence tomography.

Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 mum), and with a depth penetration of 1.5 - 2.

High-speed optical coherence tomography of laser iridotomy.

Purpose: To describe high-speed (4000 axial scans/s) optical coherence tomography (OCT) findings in a patient with narrow angles.

Design: Interventional case report.

Methods: A 56-year-old woman was found to have occludable narrow angles on OCT screening.

In vivo optical coherence tomography imaging of the pancreatic and biliary ductal system.

Background: In vivo optical coherence tomography (OCT) imaging has not yet been applied to the pancreatic ductal system. The aim of this study was to obtain in vivo OCT images of dog pancreatic and biliary ducts, and to correlate the images with histology.

Methods: Images of dog pancreatic and biliary ducts were obtained by using an in vivo OCT probe introduced through the respective papillary orifices.

Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: a prospective, double-blinded study.

Background: Endoscopic optical coherence tomography (EOCT) is a high-resolution, cross-sectional tissue-imaging technique that provides microscopic morphologic information. EOCT should detect dysplasia in Barrett's epithelium, but this has not been established in a prospective blinded study. This study evaluated the accuracy of EOCT for the diagnosis and the exclusion of dysplasia in patients with Barrett's esophagus.

Substance abuse relapse and factors associated with relapse in an inner-city sample of patients with dual diagnoses.

Objective: This study documented rates of substance abuse relapse and explored factors associated with sustained remission among consumers with severe mental illness in a large, urban clinical sample.

Methods: Existing clinical records of consumers with severe mental illness and co-occurring substance use disorders who had achieved remission and who were interviewed at two or more subsequent follow-up points (12 months after remission) were reviewed. Consumers who relapsed within 12 months after remission were compared with those who maintained remission on demographic, clinical, and functional indicators.

Phase-referenced Doppler optical coherence tomography in scattering media.

We present a fiber-based, low-coherence interferometer that significantly reduces phase noise by incorporating a second, narrowband, continuous-wave light source as a phase reference. By incorporating this interferometer into a Doppler OCT system, we demonstrate significant velocity noise reduction in reflective and scattering samples using processing techniques amenable to real-time implementation. We also demonstrate 90% suppression of velocity noise in a flow phantom.

Quasi-telecentric optical design of a microscope-compatible OCT scanner.

We report an optical coherence tomography (OCT) scanner design with optimized quasi-telecentric optics. This scanner achieves a uniform, Gaussian spot size of 15microm (1/e(2) diameter) over a range of 4.4mm in two orthogonal transverse scan dimensions.

Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles.

Objective: To assess the accuracy of classification of narrow anterior chamber (AC) angles using quantitative imaging by optical coherence tomography (OCT) and ultrasound biomicroscopy (UBM).

Design: Observational comparative study.

Methods: A high-speed (4000 axial scans/s) anterior segment OCT prototype was developed using a 1.

Correlation of endoscopic optical coherence tomography with histology in the lower-GI tract.

Background: Optical coherence tomography (OCT), a noninvasive optical imaging technique, provides high-resolution cross-sectional images of tissue microstructure. We developed a system for real-time endoscopic OCT (EOCT) of the human GI tract. During clinical trials, the structure of mucosa and submucosa, glands, blood vessels, pits, villi, and crypts was observed in a range of GI organs.

Optical coherence tomography: a new method to assess aneurysm healing.

Object: Aneurysmal subarachnoid hemorrhage affects approximately 10/100,000 people per year. Endovascular coil embolization is used increasingly to treat cerebral aneurysms and its safety and durability is rapidly developing. The long-term durability of coil embolization of cerebral aneurysms remains in question; patients treated using this modality require multiple follow-up angiography studies and occasional repeated treatments.

Anterior chamber width measurement by high-speed optical coherence tomography.

Objective: To measure anterior chamber (AC) width and other dimensions relevant to the sizing of phakic intraocular lenses (IOLs) with a high-speed optical coherence tomography (OCT) system.

Design: Cross-sectional observational study.

Participants: Both eyes of 20 normal volunteers.

How evidence-based practices contribute to community integration.

Since the groundbreaking work of the Robert Wood Johnson Conference in 1998 identifying six evidence-based practices (EBPs) for people with severe mental illness (SMI), the mental health field has moved in the direction of re-examination and redesign of service systems. Surprisingly, one area that has not been fully explicated is the role that EBPs play in promoting community integration. In this paper, we explain how community integration is a unifying concept providing direction and vision for community mental health for people with SMI.

Implementing evidence-based psychosocial practices: lessons learned from statewide implementation of two practices.

Objective: As part of this national project, we examined barriers and strategies to implementation of two evidence-based practices (EBPs) in Indiana.

Background: Despite many advances in the knowledge base regarding mental health treatment, the implementation of EBPs in real-world setting remains poorly understood. The National EBP Project is a multi-state study of factors influencing implementation of EBPs.

Polarization-resolved second-harmonic-generation optical coherence tomography in collagen.

We describe a novel imaging technique, second-harmonic-generation optical coherence tomography (SHOCT). This technique combines the spatial resolution and depth penetration of optical coherence tomography (OCT) with the molecular sensitivity of second-harmonic-generation spectroscopy. As a consequence of the coherent detection required for OCT, polarization-resolved images arise naturally.

Development of the DPA Fidelity Scale: using fidelity to define an existing vocational model.

Psychiatric rehabilitation practices are often poorly defined, hindering implementation, research, and dissemination efforts. Documentation of adherence to a specific psychiatric rehabilitation approach is particularly important in conducting randomized controlled trials. This paper outlines steps taken to define and measure the Diversified Placement Approach (DPA), a well-regarded vocational program for people with severe mental illnesses.