Ixazomib, pomalidomide and dexamethasone in relapsed or refractory multiple myeloma characterized with high-risk cytogenetics: the IFM 2014-01 study.

Not available.

Advanced Radiation DOSimetry phantom (ARDOS): a versatile breathing phantom for 4D radiation therapy and medical imaging.

A novel breathing phantom was designed for being used in conventional and ion-beam radiotherapy as well as for medical imaging. Accurate dose delivery and patient safety are aimed to be verified for four-dimensional (4D) treatment techniques compensating for breathing-induced tumor motion. The phantom includes anthropomorphic components representing an average human thorax.

Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma.

Background: High-dose chemotherapy plus autologous stem-cell transplantation has been the standard treatment for newly diagnosed multiple myeloma in adults up to 65 years of age. However, promising data on the use of combination therapy with lenalidomide, bortezomib, and dexamethasone (RVD) in this population have raised questions about the role and timing of transplantation.

Methods: We randomly assigned 700 patients with multiple myeloma to receive induction therapy with three cycles of RVD and then consolidation therapy with either five additional cycles of RVD (350 patients) or high-dose melphalan plus stem-cell transplantation followed by two additional cycles of RVD (350 patients).

On the applicability of [F]FBPA to predict L-BPA concentration after amino acid preloading in HuH-7 liver tumor model and the implication for liver boron neutron capture therapy.

Introduction: In recent years extra-corporal application of boron neutron capture therapy (BNCT) was evaluated for liver primary tumors or liver metastases. A prerequisite for such a high-risk procedure is proof of preferential delivery and high uptake of a B-pharmaceutical in liver malignancies. In this work we evaluated in a preclinical tumor model if [F]FBPA tissue distribution measured with PET is able to predict the tissue distribution of [B]L-BPA.

Prevalence of malnutrition in children under five and school-age children in Milot Valley, Haiti.

Objectives: This research aims to provide child malnutrition prevalence data from Haiti's Milot Valley to inform the design and implementation of local health interventions.

Study Design: This cross-sectional study measured underweight, stunting, and wasting/thinness using international growth standards.

Methods: Anthropometric measurements (height/length and weight) were taken on a convenience sample of 358 children aged 0-14 years.

Microdosimetric assessment of the radiation quality of a therapeutic proton beam: comparison between numerical simulation and experimental measurements.

Using protons for the treatment of ocular melanoma (especially of posterior pole tumours), the radiation quality of the beam must be precisely assessed to preserve the vision and to minimise the damage to healthy tissue. The radiation quality of a therapeutic proton beam at the Centre Antoine Lacassagne in Nice (France) was measured using microdosimetric techniques, i.e.

Overview of on-board measurements during solar storm periods.

Radiation exposure of aircraft crew caused by cosmic radiation is regulated in Europe by the European Community Council Directive 96/29/EURATOM and implemented into law in almost every country of the European Union. While the galactic cosmic radiation (GCR) leads on average to an exposure of about 3 mSv per year, solar cosmic radiation can lead to 1 mSv per one subsonic flight during solar storm periods. Compared to GCR, solar cosmic radiation shows a much softer proton spectrum but with a larger contribution of several orders of magnitude.

Comparison of codes assessing galactic cosmic radiation exposure of aircraft crew.

The assessment of the exposure to cosmic radiation onboard aircraft is one of the preoccupations of bodies responsible for radiation protection. Cosmic particle flux is significantly higher onboard aircraft than at ground level and its intensity depends on the solar activity. The dose is usually estimated using codes validated by the experimental data.

AVIDOS--a software package for European accredited aviation dosimetry.

AVIDOS is a computer code used for the dose assessment of aircraft crew exposed to cosmic radiation. The code employs a multiparameter model built upon simulations of cosmic radiation exposure done using the FLUKA Monte Carlo code. AVIDOS calculates both ambient dose equivalent H*(10) and effective dose E for flight routes over the whole world at typically used altitudes and for the full range of solar activity.

Analysis of computational problems expressing the overall uncertainties: photons, neutrons and electrons.

In the frame of the EU Coordination Action CONRAD (coordinated network for radiation dosimetry), WP4 was dedicated to work on computational dosimetry with an action entitled 'Uncertainty assessment in computational dosimetry: an intercomparison of approaches'. Participants attempted one or more of eight problems. This paper presents the results from problems 4-8-dealing with the overall uncertainty budget estimate; a short overview of each problem is presented together with a discussion of the most significant results and conclusions.

Lanthanide-loaded paramagnetic liposomes as switchable magnetically oriented nanovesicles.

Osmotically shrunken liposomes loaded with paramagnetic lanthanide(III) complexes orient in a static magnetic field according to the sign of their magnetic susceptibility anisotropy (Deltachi). The magnitude and sign of Deltachi are modulated by the magnetic properties of the Ln (III) ion, by the structural characteristics of the metal chelate, and by the stereochemical arrangement of the lipophilic substituents.

First ex-vivo MRI co-localization of two LIPOCEST agents.

One of the major advantages of the CEST methodology deals with the possibility of visualizing more probes in the same MR image voxels. This is a unique property within the contrast media that act on the (1)H-NMR signal of water protons, and it might considerably improve the potential of the technique. In addition to displaying sufficiently different resonance frequencies of their mobile protons, it is also important that the CEST agents designed for this application are highly sensitive.

Uncertainty budget for a whole body counter in the scan geometry and computer simulation of the calibration phantoms.

At the Austrian Research Centers Seibersdorf (ARCS), a whole body counter (WBC) in the scan geometry is used to perform routine measurements for the determination of radioactive intake of workers. The calibration of the WBC is made using bottle phantoms with a homogeneous activity distribution. The same calibration procedures have been simulated using Monte Carlo N-Particle (MCNP) code and FLUKA and the results of the full energy peak efficiencies for eight energies and five phantoms have been compared with the experimental results.

Determinations of H(10) and its dose components onboard aircraft.

Aircrew is in general receiving a higher average annual dose than other occupationally exposed personnel, and about half of the effective dose is deposited by high-LET neutron secondaries. A recent investigation of the cancer incidence following the atomic bombs at Hiroshima and Nagasaki has put forward the possibility that the relative biological efficiency for neutrons could be underestimated. If so, the effective dose to aircrew from this component would increase and the estimation of this component will become even more important.

Measurements and simulations of the radiation exposure to aircraft crew workplaces due to cosmic radiation in the atmosphere.

As required by the European Directive 96/29/Euratom, radiation exposure due to natural ionizing radiation has to be taken into account at workplaces if the effective dose could become more than 1 mSv per year. An example of workers concerned by this directive is aircraft crew due to cosmic radiation exposure in the atmosphere. Extensive measurement campaigns on board aircrafts have been carried out to assess ambient dose equivalent.

Calibration and background measurements with a tissue equivalent proportional counter.

A tissue-equivalent-proportional counter (TEPC) instrument has been used as the reference instrument for cosmic radiation measurement at flight altitudes by several institutes. For purposes of characterisation the response of the instrument has been investigated under different standard radiation conditions, in terms of radiation particle, energy and angle of incidence. Photon sources and photon beams of energies up to 6.

Measurement and simulation of lineal energy distribution at the CERN high energy facility with a tissue equivalent proportional counter.

The response of a tissue equivalent proportional counter (TEPC) in a mixed radiation field with a neutron energy distribution similar to the radiation field at commercial flight altitudes has been studied. The measurements have been done at the CERN-EU High-Energy Reference Field (CERF) facility where a well-characterised radiation field is available for intercomparison. The TEPC instrument used by the ARC Seibersdorf Research is filled with pure propane gas at low pressure and can be used to determine the lineal energy distribution of the energy deposition in a mass of gas equivalent to a 2 microm diameter volume of unit density tissue, of similar size to the nuclei of biological cells.

The results of cosmic radiation in-flight TEPC measurements during the CAATER flight campaign and comparison with simulation.

The European-Commission-supported project DOSMAX (Dosimetry of Aircrew Exposure to Radiation During Solar Maximum) was aimed at measuring aircrew exposure to cosmic radiation on-board the aircraft during solar maximum. During a dedicated international comparison mission (Co-ordinated Access to Aircraft for Transnational Environmental Research; CAATER) different measurement techniques have been compared by six European institutes (Results of the CAATER Mission, DOSMAX Meeting, Dublin, June 2004). In this paper, we present the tissue-equivalent proportional counter (TEPC) measurements carried out by ARC Seibersdorf research (ARCS), Austria, and Institut de Radioprotection et de Sûreté Nucléaire (IRSN), France, together with a comparison with simulation results under the same conditions.

FLUKA simulation of TEPC response to cosmic radiation.

The aircrew exposure to cosmic radiation can be assessed by calculation with codes validated by measurements. However, the relationship between doses in the free atmosphere, as calculated by the codes and from results of measurements performed within the aircraft, is still unclear. The response of a tissue-equivalent proportional counter (TEPC) has already been simulated successfully by the Monte Carlo transport code FLUKA.

Shielding variation effects for 250 MeV protons on tissue targets.

This paper provides results of computer simulation studies with the goal to analyse issues regarding radiation protection for personnel, patients and third persons involved in hadron therapy treatment. The treatment room and the patient are modelled by simple cylindrical geometries at incident proton energies of 250 MeV. Monte Carlo simulations of the energy and angular dependence of proton, neutron and photon radiation fields and resulting ambient dose equivalent distributions outside the shielding walls are performed.

Dosimetric considerations on TEPC fluka-simulation and measurements.

The response of a tissue equivalent proportional counter (TEPC) has been simulated with the Monte Carlo transport code FLUKA. The absorbed dose distribution of lineal energy y has been determined for several monoenergetic photon and neutron sources. The agreement between the calculated results and the measurements carried out with different well-known sources is well demonstrated.