Publications by authors named "Roll F"

Tissue morphogenesis remains poorly understood. In plants, a central problem is how the 3D cellular architecture of a developing organ contributes to its final shape. We address this question through a comparative analysis of ovule morphogenesis, taking advantage of the diversity in ovule shape across angiosperms.

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Background: Early post-stroke seizures (EPSS) are associated with an increased risk of mortality and post-stroke epilepsy. This study aimed to identify potential risk factors for EPSS, focusing on blood parameters, such as the neutrophil-to-lymphocyte ratio (NLR), which is a biomarker for inflammation.

Methods: Patients treated for ischemic stroke between 2017 and 2019 were retrospectively identified.

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Introduction: Little is known about splenic rupture in patients who develop systemic acquired A amyloidosis. This is the first report of a case of atraumatic splenic rupture in a patient with acquired A amyloidosis from chronic injection drug use.

Case Presentation: A 58-year-old Caucasian man with a long history of injection drug use, hospitalized for infective endocarditis, experienced atraumatic splenic rupture and underwent splenectomy.

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Despite the fact that it had an exceptional security program that has evolved over the years, Barnes-Jewish Hospital sought an outside perspective to identify additional areas for improvement. In this article, the authors describe what improvements were achieved, and how they were brought about.

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This two perspective article addresses the issue of vendor screening and identification. It describes a process now in place at a hospital that complies with new Federal regulations for screening and managing vendors who enter a healthcare facility.

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A candid and detailed description of the author's heart attack and its aftermath with advice to his colleagues on how to become more proactive in identifying and dealing with the risk factors associated with coronary heart disease.

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An objective, outside review of an institution's security program should be reasonable, appropriate and cost-effective. This article identifies the methods and ingredients of such a review.

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To get additional dollars or avoid budget cuts or personnel reductions, healthcare security directors should consider a budget approach that best justifies the needs of the department or organization.

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Health care systems have continued to evolve over the past several years. Some have been successful, some have reverted back to stand-alone or affiliated hospitals, and others continue to struggle with the system concept. Security departments must identify their new roles as this evolution plays out.

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The many different security models in place in health facilities across the country--including 'campus police,' off-duty officers, proprietary programs, contract security, and combined proprietary and contract security--will come under increased scrutiny by JCAHO in the event of an internal or external disaster situation. In this article, the author addresses the need for reevaluating current security models so that they can be defended as reasonable and appropriate should a future incident or litigation call them into question.

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Programs for dealing with terrorism prior to the events of September 11, 2001 are inadequate for the new terrorist threat that may severely hamper a hospital's ability to render services. The article outlines areas of concern that must be addressed if hospitals are to fulfill their roles as major community resources in case of a terrorist event.

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Patients with hip fractures are at high risk for pressure ulcer development, yet few recent studies have addressed risk assessment in this population. In this retrospective medical record survey, records of a random sample of California Medicare beneficiaries with hip fractures admitted to acute care hospitals in 1995 were selected for abstraction. Medical record abstraction (n = 545) revealed that risk assessment was performed on only 44.

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OSHA has developed guidelines that are the agency's recommendations for reducing workplace violence, specifically in the health care and social services work environments. These guidelines are intended to be advisory in nature as well as informational in content to assist employers in establishing a safe workplace by creating effective violence prevention programs. These guidelines should be used and adapted to meet the specific needs and resources of each place of employment.

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Expression of the group of cytokines known as transforming growth factor-beta (TGF-beta 1, -beta 2 and -beta 3) is increased during liver regeneration induced by a 70% partial hepatectomy. The origin of these changes was examined in purified isolates of hepatocytes, sinusoidal endothelial cells, Kupffer cells (liver macrophages), and lipocytes (Ito or stellate cells) from normal and regenerating liver. In normal liver, TGF-beta 1 and -beta 2 levels were relatively high in sinusoidal endothelial cells and Kupffer cells.

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To survive in today's economic climate, security directors must also be good business managers. In this article, the author offers suggestions for achieving this goal.

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The oxidation of arachidonic acid in a superoxide-generating environment results in the formation of a potent chemoattractant that appears to be identical to a chemotactic material generated by hepatocytes when they metabolize alcohol. The product was extracted, chromatographed and characterized by physical methods including GC/MS. The physical properties are consistant with the parent structure: 19-hydroperoxy, 20-hydroxyarachidic acid.

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Open fenestrations are a conspicuous feature of sinusoidal endothelial cells and allow free movement of plasma into the space of Disse. In hepatic fibrosis, the number of fenestrations decreases as interstitial collagen increases in the liver, a change that correlates with deposition of extracellular matrix in the space of Disse. In this study, the possibility of a causal relationship between altered fenestral morphology and perisinusoidal matrix has been examined by culturing rat sinusoidal endothelial cells on individual matrix proteins or on a native matrix consisting of human amniotic membrane with interstitial collagen (types I and III) on one side and basement membrane proteins (collagen types IV and V and laminin) on the other.

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