Publications by authors named "Rolf-Michael Kuester"
Objective: To evaluate safety and effectiveness of adalimumab (ADA) in polyarticular-course juvenile idiopathic arthritis (JIA) in the STRIVE registry.
Methods: STRIVE enrolled patients with polyarticular-course JIA into 2 arms based on treatment with methotrexate (MTX) alone or ADA with/without MTX (ADA ± MTX). Adverse events (AEs) per 100 patient-years of observation time were analyzed by registry arm.
Objective: Evolving inflammatory bowel disease (IBD) is a matter of interest in patients with juvenile idiopathic arthritis (JIA) and might be associated with JIA therapy.
Methods: Data from the German biologics registry (Biologika in der Kinderrheumatologie; BiKeR) from 2001 to 2013 were analyzed.
Results: There were 3071 patients with 8389 patient-years (PY) of observation followed.
Article Synopsis
- The study focuses on granulomatosis with polyangiitis (GPA) in children, analyzing data from 56 pediatric patients diagnosed before age 18.
- Most of the patients were female (68%) and Caucasian (82%), with a median diagnosis age of around 11.7 years and an average diagnosis delay of 4.2 months.
- Clinical signs were predominantly seen in the ears, nose, throat, and respiratory system, with a notable percentage of patients testing positive for ANCA-PR3 and presenting with haematuria/proteinuria, showing different patterns of organ involvement compared to adults.
Objectives: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease affecting children. Even if remission is successfully induced, about half of the patients experience a relapse after stopping anti-inflammatory therapy. The present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent.
View Article and Find Full Text PDF