Patterned surfaces segregate compliant microcapsules.

For both biological cells and synthetic microcapsules, mechanical stiffness is a key parameter since it can reveal the presence of disease in the former case and the quality of the fabricated product in the latter case. To date, however, assessing the mechanical properties of such micron-scale particles in an efficient, cost-effective means remains a critical challenge. By developing a three-dimensional computational model of fluid-filled, elastic spheres rolling on substrates patterned with diagonal stripes, we demonstrate a useful method for separating cells or microcapsules by their compliance.

Modeling the release of nanoparticles from mobile microcapsules.

The authors present a novel computational approach to simulate both the release of nanoparticles from a microcapsule, which is moving through a microchannel, and the adsorption of the released particles onto the channel walls. By integrating the lattice spring model for the micromechanics of elastic solids and the lattice Boltzmann model for fluid dynamics, they simulate the relevant fluid-structure interactions in the system. In particular, they capture the dynamic interactions among the capsule's elastic shell, the encapsulated fluid, and the external, host solution.

Healing substrates with mobile, particle-filled microcapsules: designing a 'repair and go' system.

We model the rolling motion of a fluid-driven, particle-filled microcapsule along a heterogeneous, adhesive substrate to determine how the release of the encapsulated nanoparticles can be harnessed to repair damage on the underlying surface. We integrate the lattice Boltzmann model for hydrodynamics and the lattice spring model for the micromechanics of elastic solids to capture the interactions between the elastic shell of the microcapsule and the surrounding fluids. A Brownian dynamics model is used to simulate the release of nanoparticles from the capsule and their diffusion into the surrounding solution.

Designing a simple ratcheting system to sort microcapsules by mechanical properties.

Using computational modeling, we analyze the fluid-driven motion of compliant particles over a rigid, saw-toothed surface. The particles are modeled as fluid-filled elastic shells and, thus, simulate ex vivo biological cells or polymeric microcapsules. Through the model, we demonstrate how the patterned surface and an oscillatory shear flow can be combined to produce a ratcheting motion, yielding a straightforward method for sorting these capsules by their relative stiffness.

Modeling the interactions between deformable capsules rolling on a compliant surface.

By integrating mesoscale models for hydrodynamics and micromechanics, we examine the fluid-driven motion of pairs of capsules on a compliant, adhesive substrate. The capsules, modeled as fluid filled elastic shells, represent cells or polymeric microcapsules. We show that both the relative and the average velocities of two closely spaced, rolling capsules depends on the elasticity of the capsules, the adhesive interaction between the capsules and the substrate, and the compliance of the substrate.

Designing compliant substrates to regulate the motion of vesicles.

By integrating mesoscale models for hydrodynamics and micromechanics, we examine fluid-driven motion of vesicles on compliant surfaces. The vesicles, modeled as fluid-filled elastic shells, represent biological cells or polymeric microcapsules. Focusing on nonspecific interactions between these vesicles and synthetic substrates, we isolate mechanically and topographically patterned surfaces that transmit stop and go instructions, causing the vesicles to halt at specific locations, and with an increase in the flow velocity, to resume moving.

Lattice-Boltzmann method for simulating spherical bubbles with no tangential stress boundary conditions.

A lattice-Boltzmann boundary rule has been developed to recover the slip boundary condition at a liquid-gas interface. This rule enables one to use a single-component lattice-Boltzmann model to simulate bubbly flows where bubbles are nearly spherical and coalescence is prohibited. Numerical tests showed this method to be robust and accurate in simulating both steady and unsteady flows around spherical bubbles in the Reynolds number range 0 View Article and Find Full Text PDF

Modeling the flow of fluid/particle mixtures in microchannels: encapsulating nanoparticles within monodisperse droplets.

We develop a hybrid computational approach for simulating mixtures of binary fluids and mobile, submicron particles. The model couples a lattice Boltzmann method for the binary fluid with a Brownian dynamics model for the particles. The particles can exhibit preferential wetting interactions with the different components of the fluid.

Newtonian fluid meets an elastic solid: coupling lattice Boltzmann and lattice-spring models.

We integrate the lattice Boltzmann model (LBM) and lattice spring model (LSM) to capture the coupling between a compliant bounding surface and the hydrodynamic response of an enclosed fluid. We focus on an elastic, spherical shell filled with a Newtonian fluid where no-slip boundary conditions induce the interaction. We calculate the "breathing mode" oscillations for this system and find good agreement with analytical solutions.