Publications by authors named "Rolf Gemperli"

Background: Abdominoplasty is one of the most commonly performed procedures. Despite improvements in the abdominoplasty technique, seroma is the most common complication, ranging from 5 to 43%. This study aimed to review the literature to compare therapeutic strategies to prevent common adverse events in abdominoplasty.

View Article and Find Full Text PDF

Background: Acute traumatic wounds often require prolonged healing time and hospitalization. Negative-pressure wound therapy with instillation and dwell time (NPWTi-d) has demonstrated effectiveness in accelerating patient healing over traditional NPWT, and its benefits are well established in the treatment of chronic infected wounds. However, randomized studies examining the use of NPWTi-d in acute traumatic wounds are scarce.

View Article and Find Full Text PDF

Agents that inhibit programmed cell death (IPD-1) in T lymphocytes are indicated for patients with advanced cancer. However, some individuals may develop endocrinological conditions, such as diabetes, thyroid dysfunction, and lipodystrophy, after treatment. This systematic review and case report of IPD-1 lipodystrophies describes a patient who received nivolumab treatment for advanced clear cell renal carcinoma and subsequently developed diabetes as well as facial and body lipodystrophy.

View Article and Find Full Text PDF
Article Synopsis
  • Ozone therapy may enhance healing for diabetic foot ulcers (DFUs) by boosting antioxidant enzyme activity, regulating growth factors, and improving blood flow while also providing antibacterial effects.
  • * A systematic review revealed six studies that met eligibility criteria, showing ozone therapy led to higher healing rates, shorter hospital stays, and better blood glucose levels among patients.
  • * Despite promising findings, the studies had significant risk of bias, highlighting the need for more rigorous research to confirm ozone therapy's effectiveness in treating DFUs.
View Article and Find Full Text PDF

Background: Patients undergoing perineal defect reconstruction with the internal pudendal artery perforator (IPAP) flap traditionally face 5 days of postoperative bed rest (BR) to minimize surgical risks. However, prolonged BR can exacerbate postoperative physiologic changes such as increased fatigue, reduced body mass, and declining lung function, while also leading to complications such as pneumonia, delirium, deep vein thrombosis, and pressure injuries. This study assessed the effectiveness, feasibility, and safety of an adapted early mobilization (EM) program for these patients.

View Article and Find Full Text PDF

Introduction: The large mixture of races in Brazil gives the nose its distinctive composition, which makes rhinoplasty difficult for these patients. Every patient should have their anatomy thoroughly examined on an individual basis, as there is no unique strategy that works for all situations.

Methodology: This is a narrative overview of the last 10 years' worth of literature that describes the ethnic traits of each nose, with a particular emphasis on the Brazilian nose, and talks about the major surgical approaches that can be applied in these situations.

View Article and Find Full Text PDF

Background: Osteotomies are important maneuvers in the plastic surgeon's arsenal for the nasal dorsum treatment. However, there is a concern regarding a possible medialization of the inferior turbinate's heads and narrowing of the internal nasal valve if the Webster's triangle is not preserved.

Objectives: To analyze the mobilization of the inferior turbinates during primary rhinoplasty after lateral osteotomies.

View Article and Find Full Text PDF

Skin flaps are employed to cover cutaneous denuded surfaces, but ensuing flap necrosis often occurs. Previously, rats with myocardial infarction treated with lipid-core nanoparticles (LDE) loaded with methotrexate (MTX) improved myocardial irrigation and reduced necrosis. Here, the aim was to investigate the efficacy of LDE-MTX to preserve the viability of cutaneous flaps and its implications for surgical wound healing.

View Article and Find Full Text PDF

Introduction: Degloving soft tissue injuries (DSTIs) involve skin and tissue detachment from muscle or fascia. Surgical treatments exist, but they cannot prevent necrosis.

Objective: Our aim was to investigate the effects of hyperbaric oxygen therapy (HOT) and adipocyte stem cell (ASC) treatment on tissue viability in degloving injuries in a murine model.

View Article and Find Full Text PDF

Introduction: Fat graft (FG) absorption rate varies from 20 to 80% in two years. Recently, several bioengineering techniques were applied to improve FG retention rate. Numerous studies investigated the use of adipocyte-derived stem cells (ASC) as FG enrichment.

View Article and Find Full Text PDF
Article Synopsis
  • Around 1%-2% of the global population will experience chronic skin wounds in their lifetime, and patient-reported outcome measures (PROM) are used to gauge their quality of life.
  • The WOUND-Q tool was created to assess various types of wounds and is beneficial for use in different countries due to its broad applicability.
  • This study focused on translating and adapting the WOUND-Q tool into Brazilian Portuguese, involving independent translations, consensus meetings, and cognitive testing, ultimately resulting in a validated final version.
View Article and Find Full Text PDF

Background: Capsular contracture is a common complication affecting about 80% of patients who receive radiotherapy after breast reconstruction with silicone prostheses. This study examines the use of adipocyte stem cells (ASCs) to treat capsular contracture.

Methods: Thirty rats were operated on to implant a minisilicone prosthesis in the dorsal region.

View Article and Find Full Text PDF

Background: The sudden increase of intensive care unit patients during the coronavirus pandemic led to an increase in the incidence of sacral pressure lesions. Despite being ambulating patients, in many cases the lesions were deep (Grade III and IV), mainly due to the long-term intubation and being bedridden during the pandemic. Most of these wounds necessitated surgical repair.

View Article and Find Full Text PDF

Introduction: Post-burn hypertrophic scars are an important cause of physical discomfort, limitation of movements, psychological disorders, low self-esteem and reduced quality of life. Treatment for this condition is complex and involves several options. Microneedling, also known as minimally invasive percutaneous collagen induction, is an affordable minimally invasive option that can be combined with other treatments, including ablative ones.

View Article and Find Full Text PDF

Purpose: Enterocutaneous fistula (ECF) is a condition in which there is an abnormal connection between the intestinal tract and the skin. It can lead to high morbidity and mortality rates despite the availability of therapeutic options. Stem cells have emerged as a potential strategy to treat ECF.

View Article and Find Full Text PDF

Introduction: The COVID 19 pandemic has resulted in an increased number of patients requiring intubation and intensive care. This has led to an increased incidence of sacral pressure ulcers requiring surgical management. We report our experience of COVID 19 related sacral pressure ulcers requiring surgical reconstruction.

View Article and Find Full Text PDF

Background:  Autologous tissue has become the gold standard in breast reconstruction. The use of a deep inferior epigastric perforator (DIEP) flap has the advantages of giving a natural appearance to the reconstructed breast and being associated with lower morbidity at the donor site when compared with the transverse rectus abdominis myocutaneous flap. Venous complications such as venous thrombosis and insufficiency remain the main causes of flap loss and surgical revisions.

View Article and Find Full Text PDF

Introduction: obesity is one of the most common diseases worldwide, and the most effective treatment to it is the bariatric surgery. One of the negative impacts of this procedure is the body dysmorphia caused by overhanging skin. In Brazil, the national health system - Sistema Único de Sáude (SUS) - provide body contouring surgery to treat post-bariatric patients, since 2007.

View Article and Find Full Text PDF

Background And Aims: Skin grafting is the single most effective method to close a chronic wound. The current standard of care is to use meshed split thickness skin grafts. This entails the use of surgical instruments that need to be autoclaved and to have a power source, which usually requires an OR facility.

View Article and Find Full Text PDF

Unlabelled: Approximately 80% of patients submitted to radiotherapy develop radiodermatitis. Photobiomodulation based on light-emitted diode (LED) is one of the therapeutic strategies for treating inflammation. This study aimed to investigate the effect of the photobiomodulation with two wavelengths, in an acute radiodermatitis animal model.

View Article and Find Full Text PDF

Burn injuries are a significant cause of morbidity and mortality in the Brazilian population. We conducted this study in a tertiary hospital in Brazil to discover the epidemiological characteristics of patients with burn injuries. We conducted a cohort review of patients admitted to the burn unit of our institute during a 5-year period.

View Article and Find Full Text PDF

Purpose: To analyze the cytotoxicity and cell in porcine-derived decellularized skin matrix.

Methods: We analyzed the effect of multiple decellularization processes by histological analysis, DNA quantification, and flow cytometry. Subsequently, we analyzed the most appropriate hydrogel concentration to minimize cytotoxicity on fibroblast culture and to maximize cell proliferation.

View Article and Find Full Text PDF