Synopsis of recent research by authors named "Roland Wakiec"
- Roland Wakiec's research primarily focuses on understanding multidrug resistance in fungi, particularly through the study of yeast strains like *Saccharomyces cerevisiae* and *Candida albicans*, highlighting the role of ABC multidrug efflux pumps in conferring resistance to antifungal agents.
- His findings reveal that yeast strains overexpressing specific drug efflux transporter genes display enhanced susceptibility to oligopeptide antifungals, suggesting potential therapeutic strategies to combat multidrug-resistant fungal infections.
- Wakiec has also synthesized various novel compounds, such as oxathiolone fused chalcones and glutamine analogues, demonstrating promising antibacterial and antifungal activities, which contribute to the search for effective treatments against resistant microbial strains.
