Publications by authors named "Roland Tomb"
Article Synopsis
- Telogen effluvium (TE) is a common cause of hair loss in women, and effective treatment should target its causes, often using various topical and oral medications.
- This study evaluated how iron supplementation affects women's satisfaction levels with TE treatment, involving 200 women aged 18 to 65 who were diagnosed with TE and not undergoing other specific treatments.
- Results showed that women with higher initial ferritin levels were more satisfied with the treatment, particularly when given higher doses of iron for a longer period, suggesting positive outcomes even for those without low ferritin.
Article Synopsis
- Oral isotretinoin is identified as the most effective treatment for acne, and this study aimed to assess the side effects related to different brands of the medication used at a single center from 2015 to 2020.
- A total of 468 patients were evaluated, predominantly female (68.6%), with an average age of 21 years; various isotretinoin brands were used with Roaccutane being the most common.
- The study found xerosis to be the most common side effect, while distinct side effects were linked to specific brands, such as hypercholesterolemia with Roaccutane and abnormal liver tests with Acnotren, suggesting that both the drug brand and patient characteristics influence side effect prevalence.
Objectives: To explore the short- and long-term effects of UVB phototherapy preceding a fractional CO laser-UVB protocol in patients with resistant nonsegmental vitiligo.
Materials And Methods: This single-center, prospective, split-face/body, evaluator-blinded study included adult patients with stable vitiligo refractory to conventional treatments. Two symmetrical lesions were selected.
Article Synopsis
- The study aimed to evaluate how much Lebanese parents know about melanoma and how they protect their children from it.
- A survey was distributed to parents through their kids in three different schools.
- Results showed that many parents are not diligent about sun protection, with only 23.5% consistently covering their children's skin and 74.1% not always using sunscreen, indicating a need for more awareness campaigns about melanoma.
Basal cell carcinoma (BCC) data coming from the Levantine coast of the Mediterranean Sea are limited. The study aimed to primarily analyze the demographic, clinical, pathological, and prognostic characteristics of BCC in this region of the world and secondarily identify features associated with high-risk, recurrent, or multiple BCCs. Patients with at least one diagnosis of BCC registered in the pathology department between January 2015 and December 2019 were included in this analytical retrospective single-center cohort study.
View Article and Find Full Text PDFSézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL) in which the human Telomerase Reverse Transcriptase () gene is re-expressed. Current available treatments do not provide long-term response. We previously reported that Histone deacetylase inhibitors (HDACi, romidespin and vorinostat) and a DNA methyltransferase inhibitor (DNMTi, 5-azacytidine) can reduce expression without altering the methylation level of promoter.
View Article and Find Full Text PDFBackground: Acne is highly prevalent among teenagers and young adults, with proven negative psychological and emotional impact. To our knowledge, no study has been conducted to quantify the repercussions of acne on quality of life (QoL) and self-esteem in Lebanon.
Objective: This study aimed to highlight the effect of acne treatment on QoL and self-esteem of Lebanese adolescents and young adults.
Article Synopsis
- Basal cell carcinoma (BCC) is a common skin cancer that is highly treatable in its early stages and rarely spreads to other parts of the body.
- Though current treatments are effective for early BCC, advanced or metastatic cases present a challenge, highlighting the need for new treatment options.
- Recent advancements have included the use of immune checkpoint inhibitors, with an anti-PD1 drug recently approved for advanced BCC, prompting reviews of existing studies and clinical evidence supporting their effectiveness and safety.
Background: Lichen planus (LP) is a chronic inflammatory disorder usually occurring in middle-aged adults. Data are scarce in the pediatric population.
Objective: To describe the patients' characteristics, clinical presentation, and management of pediatric LP.
Article Synopsis
- Basal cell carcinoma (BCC) is the most common type of non-melanoma skin cancer, with its incidence rising significantly, particularly among individuals under 40.
- This study analyzed tumors from 25 Lebanese patients under 40, utilizing Next Generation Sequencing to assess 150 cancer-related genes, resulting in the detection of 202 genetic variations in 48 genes.
- The findings indicate that the PTCH1 gene is most commonly affected (in 64.3% of cases), followed by TP53 and SMO, suggesting important genetic pathways involved in BCC among young patients, although further research with a larger sample size is recommended.
Severe Granulomatous Rosacea with Cutaneous Lupus Erythematosus.
J Clin Aesthet Dermatol
February 2021
Article Synopsis
- Rosacea and cutaneous lupus erythematosus (CLE) are both long-term inflammatory skin conditions.
- A unique case is presented involving a 38-year-old woman who showed symptoms of granulomatous rosacea (GR) alongside CLE.
- The diagnosis was confirmed through clinical evaluation and pathological analysis, marking a potentially novel link in medical literature.
Successful treatment of pediatric keratosis lichenoides chronica with narrow-band UVB phototherapy: A case report and literature review.
Photodermatol Photoimmunol Photomed
November 2021
Gianotti-Crosti syndrome (GCS) is a self-limited benign dermatosis, clinically characterized by a monomorphic papular or papulovesicular eruption symmetrically distributed on the limbs and face of children. Various viral and vaccine triggers have been associated with GCS. Recurrences are uncommon but have been reported.
View Article and Find Full Text PDFArticle Synopsis
- * Data collected from 2083 cisgender unmarried women showed low prevalence of severe STIs but high rates of inconsistent condom use (81%) and recreational drug use (33%), which are linked to various factors such as unemployment and number of sexual partners.
- * The findings emphasize the critical need for accessible and non-stigmatizing sexual health services, along with comprehensive education to empower women in making informed decisions about their sexual health.
Background: In hemiparetic patients, the skeletal muscle is mainly affected with a combination of abnormalities (denervation, remodeling, spasticity, and eventually muscular atrophy).
Objective: This study examined the role of eccentric exercise in strengthening muscles of the lower extremity and ultimately improving autonomy in patients with post-stroke hemiparesis during gait.
Methods: Thirty-seven patients hemiparetic adults were recruited, randomized into a control group (n = 19) and an intervention group receiving eccentric muscle strengthening (n = 18).
Cutaneous T-cell lymphomas (CTCLs) are telomerase-positive tumors expressing hTERT, although neither gene rearrangement/amplification nor promoter hotspot mutations could explain the hTERT re-expression. As the hTERT promoter is rich in CpG, we investigated the contribution of epigenetic mechanisms in its re-expression. We analyzed hTERT promoter methylation status in CTCL cells compared with healthy cells.
View Article and Find Full Text PDFBackground: Human papilloma virus (HPV) infection is the most common sexually transmitted disease worldwide and the main cause of genital warts. Clear recommendations for the management of urethral warts, which are often hard to detect and difficult to treat, are still lacking.
Objective: To summarize all available data describing treatment modalities of urethral warts, compare their efficacy and side effects, and provide physicians a treatment strategy outline.
Lymphomas represent a heterogeneous group of cancers characterized by clonal lymphoproliferation. Over the past decades, frequent epigenetic dysregulations have been identified in hematologic malignancies including lymphomas. Many of these impairments occur in genes with established roles and well-known functions in the regulation and maintenance of the epigenome.
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