A comparative study of dissolution characteristics of polymeric and wax granulations of theophylline and their tablets.

Matrix (non disintegrating) granules of theophylline have been formed and their dissolution characteristics investigated for sustained release application. The polymeric granulations were formed by massing the drug powder with a concentrated (40% w/w) ethanolic solution of an acrylatemethacrylate copolymer (ERS100R). Wax granulations were also formed by massing the drug powder with previously melted carnuba wax followed by screening and drying.

Multi-unit dosage formulations of theophylline for controlled release applications.

The study was carried out to investigate the drug release profiles of multi-unit dosage formulations of theophylline consisting of both the fast and slow release components in a unit dose. The fast release component consisted of conventional granules of theophylline formed by mixing the drug powder with starch mucilage (20% w/v) while the slow release component consisted of wax granulations of theophylline formed by triturating the drug powder with a melted Carnauba wax (drug:wax ratio, 4:1). The granules were either filled into capsules or tabletted.

A comparative study of the dissolution characteristics of capsule and tablet dosage forms of melt granulations of paracetamol--diluent effects.

The dissolution characteristics of melt granulations of paracetamol in capsule and tablet dosage form were compared to determine whether the dissolution characteristics of the granules can be actualized by formulating them as rapidly disintegrating tablets. The term melt granulation refers here to the wax-matrix granules that were formed by triturating the drug powder (paracetamol) with a melted carnauba wax. The matrix granules were admixed with diluents (lactose, alpha-cellulose or microcrystalline cellulose) also in granular form to prevent size separation during encapsulation or tableting.

Effect of humidity on the disintegrant property of alpha-cellulose, part II: a technical note.

The summary is that the high humidity impaired the disintegrant property of α-cellulose in all 3 tablets tested. Tablets of aspirin, which is the more hygroscopic drug, were also more sensitive to the humidity effect, while tablets of chloroquine phosphate, which is a water-soluble drug, were the least sensitive to the humidity effect. The results permit the conclusion that moisture uptake with subsequent gelling of the α-cellulose is the mechanism of impairment of its disintegrant property.

Effect of humidity on the disintegrant property of alpha-cellulose.

A study has been carried out to investigate the effect of humidity on the disintegrant property of alpha-cellulose in paracetamol tablets. The disintegrant alpha-cellulose or maize starch (for comparative studies) was incorporated intragranularly or extragranularly. The tablets were prepared by a wet granulation technique and then exposed to relative humidities (RH) 1%, 78% and 100% at an ambient temperature of 28 to 30 degrees C for various time intervals up to 2 weeks.