Bone morphogenetic protein-induced repair of the premaxillary cleft.

Purpose: The purpose of this study is to evaluate the bony regeneration of premaxillary clefts in humans using recombinant human bone morphogenetic protein type 2 in a collagen sponge carrier.

Patients And Methods: Twelve patients with unilateral clefted premaxillas were evaluated preoperatively and 4 months postoperatively. Ten patients were repaired with recombinant human bone morphogenetic protein type 2 while 2 others were grafted with anterior iliac crest particulate marrow cancellous bone.

Clinical applications of rhBMP-2 in maxillofacial surgery.

Materials And Methods: Examples of defects including mandibular continuity defects, preprosthetic atrophic alveolar ridge deficiencies, traumatic defects, and maxillary clefts were included.

Results: All patients demonstrated osseous regeneration stimulated by rhBMP-2.

Conclusion: rhBMP-2 is successful in regenerating bone in a variety of maxillofacial defects.