Gastric emptying and Ca(2+) and K(+) channels of circular smooth muscle cells in diet-induced obese prone and resistant rats.

Objective: Accelerated gastric emptying that precipitates hunger and frequent eating could be a potential factor in the development of obesity. The aim of this study was to study gastric emptying in diet-induced obese-prone (DIO-P) and DIO-resistant (DIO-R) rats and explore possible differences in electrical properties of calcium (Ca(2+) ) and potassium (K(+) ) channels of antral circular smooth muscle cells (SMCs).

Design And Methods: Whole-cell patch-clamp technique was used to measure Ca(2+) and K(+) currents in single SMCs.

Food intake and body weight responses to intermittent vs. continuous gastric electrical stimulation in diet-induced obese rats.

Background: Gastric electrical stimulation (GES) has recently been introduced as a potential therapy for the treatment of obesity. The main challenge for the new generation of devices is to achieve desired clinical outcomes at a suitably low level of energy consumption. The aim of this study is to compare the effectiveness of GES with continuous and intermittent duty cycles in reducing food intake and body weight in diet-induced obesity-prone rats.

Gastric electrical stimulation parameter dependently alters ventral medial hypothalamic activity and feeding in obese rats.

Gastric electrical stimulation (GES) has been used to treat obesity with unclear mechanisms and limited parameter ranges. This study explores effects of GES parameters on ventral medial hypothalamic (VMH) activity, feeding, and body weight in diet-induced obese (DIO) rats. For experiment 1, discharge rates were recorded in 39 gastric distension-responsive (GD-R) neurons in 12 DIO rats.

Hospital provision of uncompensated care and public program enrollment.

Hospital provision of uncompensated care is partly a function of insurance coverage of state populations. As states expand insurance coverage options and reduce the number of uninsured, hospital provision of uncompensated care should also decrease. Controlling for hospital characteristics and market factors, the authors estimate that increases in MinnesotaCare (a state-subsidized health insurance program for the working poor) enrollment resulted in a 5-year cumulative savings of $58.

Psychological intervention and antidepressant treatment in smoking cessation.

Background: Sustained-release bupropion hydrochloride and nortriptyline hydrochloride have been shown to be efficacious in the treatment of cigarette smoking. It is not known whether psychological intervention increases the efficacy of these antidepressants. This study compared both drugs with placebo.