A novel benchmark model for intelligent annotation of spectral-domain optical coherence tomography scans using the example of cyst annotation.

Background And Objectives: The lack of benchmark data in computational ophthalmology contributes to the challenging task of applying disease assessment and evaluate performance of machine learning based methods on retinal spectral domain optical coherence tomography (SD-OCT) scans. Presented here is a general framework for constructing a benchmark dataset for retinal image processing tasks such as cyst, vessel, and subretinal fluid segmentation and as a result, a benchmark dataset for cyst segmentation has been developed.

Method: First, a dataset captured by different SD-OCT vendors with different numbers of scans and pathology qualities are selected.

Choroidal thickness maps from spectral domain and swept source optical coherence tomography: algorithmic versus ground truth annotation.

Background/aims: The purpose of the study was to create a standardised protocol for choroidal thickness measurements and to determine whether choroidal thickness measurements made on images obtained by spectral domain optical coherence tomography (SD-OCT) and swept source (SS-) OCT from patients with healthy retina are interchangeable when performed manually or with an automatic algorithm.

Methods: 36 grid cell measurements for choroidal thickness for each volumetric scan were obtained, which were measured for SD-OCT and SS-OCT with two methods on 18 eyes of healthy volunteers. Manual segmentation by experienced retinal graders from the Vienna Reading Center and automated segmentation on >6300 images of the choroid from both devices were statistically compared.

Correlation of 3-Dimensionally Quantified Intraretinal and Subretinal Fluid With Visual Acuity in Neovascular Age-Related Macular Degeneration.

Importance: Robust and sensitive imaging biomarkers for visual function are an unmet medical need in the management of neovascular age-related macular degeneration.

Objective: To determine the correlation of 3-dimensionally quantified intraretinal cystoid fluid (IRC) and subretinal fluid (SRF) with best-corrected visual acuity (BCVA) in treatment-naive neovascular age-related macular degeneration and during antiangiogenic therapy.

Design, Setting, And Participants: Retrospective cohort study between November 2009 and November 2011 at an institutional referral center and reading center of patients with treatment-naive subfoveal choroidal neovascularization receiving intravitreal ranibizumab or aflibercept over 12 months.