Safety and efficacy of vemurafenib in end stage renal failure.

Background: Serine-threonine inhibitors, such as vemurafenib, are being used increasingly in cancer treatment, and the toxicity and therapeutic benefit need to be balanced carefully both before and during treatment.

Case Presentation: A patient with metastatic melanoma and end stage renal failure who was on peritoneal dialysis was treated with the serine-threonine kinase inhibitor, vemurafenib. After 5 months of treatment, a substantial response to vemurafenib was observed using imaging, but when he developed a prolonged QTc interval (common toxicity criteria (CTC) grade 3), treatment was interrupted.

Ectopic liver encountered during laparoscopic cholecystectomy.

Ectopic liver is hepatic tissue that histologically resembles the mother tissue but is located at a site away from its usual location. Initially thought to be a rare anatomical anomaly of no clinical significance, it is now increasingly recognised to be capable of causing clinically relevant pathology. More specifically, it has been associated with a higher incidence of hepatocellular carcinoma, cholelithiasis and cholecystitis.

Multiplanar reconstruction in adult intussusception: case report and literature review.

We describe the use of computed tomography (CT) with multiplanar reconstruction (MPR) in positive diagnosis of a case of enteric intussusception in an adult. To our knowledge, there have been no previous reports of the use of MPR in this setting. Intussusception in adults is an uncommon cause of bowel obstruction that usually presents with non-specific symptoms.