Early prediction of neoadjuvant treatment outcome in locally advanced breast cancer using parametric response mapping and radial heterogeneity from breast MRI.

Background: Early prediction of nonresponse is essential in order to avoid inefficient treatments.

Purpose: To evaluate if parametrical response mapping (PRM)-derived biomarkers could predict early morphological response (EMR) and pathological complete response (pCR) 24-72 hours after initiation of chemotherapy treatment and whether concentric analysis of nonresponding PRM regions could better predict response.

Study Type: This was a retrospective analysis of prospectively acquired cohort, nonrandomized, monocentric, diagnostic study.