Background: Leishmaniasis is caused by protozoans that depend on female phlebotomine sandflies as vectors. The natural habitat of these sandflies is changing due to climatic changes, affecting the immunocompromised population, as more patients get immunocompromised due to cancer therapy in the present time.
Case Report: We report the case of a 72-year-old patient with melanoma in whom we found visceral leishmaniasis mimicking hepatic metastasis in routine FDG-PET/CT.