Isolation and In Vitro and In Vivo Activity of Secondary Metabolites from Baker against Malaria Parasites.

Chemical investigation of the antimalarial medicinal plant led to the isolation of five new diterpenoids, including ajugarins VII-X (-) and teuvincenone K (), along with four known compounds, namely, 12,16-epoxy-6,11,14,17-tetrahydroxy-17(15 → 16)--5,8,11,13,15-abietapentaen-7-one (), methyl pheophorbide A (), loliolide (), and acacetin (). The chemical structures of the new compounds were elucidated using NMR spectroscopy, mass spectrometry, circular dichroism, as well as density functional theory calculations. All compounds were evaluated for activity against 3D7 malaria parasites with methyl pheophorbide A () showing the strongest activity (IC 4.