Design Optimisation of a Flat-Panel, Limited-Angle TOF-PET Scanner: A Simulation Study.

In time-of-flight positron emission tomography (TOF-PET), a coincidence time resolution (CTR) below 100 ps reduces the angular coverage requirements and, thus, the geometric constraints of the scanner design. Among other possibilities, this opens the possibility of using flat-panel PET detectors. Such a design would be more cost-accessible and compact and allow for a higher degree of modularity than a conventional ring scanner.

Anatomically Accurate, High-Resolution Modeling of the Human Index Finger Using In Vivo Magnetic Resonance Imaging.

Anatomically accurate models of a human finger can be useful in simulating various disorders. In order to have potential clinical value, such models need to include a large number of tissue types, identified by an experienced professional, and should be versatile enough to be readily tailored to specific pathologies. Magnetic resonance images were acquired at ultrahigh magnetic field (7 T) with a radio-frequency coil specially designed for finger imaging.

Hyperspectral evaluation of peritoneal fibrosis in mouse models.

Analysis of morphological changes of the peritoneal membrane is an essential part of animal studies when investigating molecular mechanisms involved in the development of peritoneal fibrosis or testing the effects of potential therapeutic agents. Current methods, such as histology and immunohistochemistry, require time consuming sample processing and analysis and result in limited spatial information. In this paper we present a new method to evaluate structural and chemical changes in an animal model of peritoneal fibrosis that is based on hyperspectral imaging and a model of light transport.

Simulation study to improve the performance of a whole-body PbF Cherenkov TOF-PET scanner.

Using Cherenkov radiation in positron emission tomography (PET) has the potential to improve the time of flight (TOF) resolution and reduce the cost of detectors. In previous studies promising TOF results were achieved when lead fluoride (PbF) crystals were used instead of a scintillator. In this work, a whole-body PbF Cherenkov TOF-PET scanner was simulated and optimized.

Assessing spectral imaging of the human finger for detection of arthritis.

Rheumatoid arthritis causes changes in the optical properties of tissues in the joints, which could be detected using spectral imaging. This has the potential for development of low cost, non-contact method for early detection of the disease. In this work, hyperspectral imaging system was used to obtain 24 images of proximal interphalangeal joints of 12 healthy volunteers.