Assessing the impact of the COVID-19 pandemic on the mental health-related hospitalization rate of youth in Canada: an interrupted time series analysis.

Introduction: This study evaluated the effect of the COVID-19 pandemic on temporal trends in mental health and addiction-related inpatient hospitalization rates among youth (aged 10-17 years) in Canadian provinces and territories (excluding Quebec) from 1 April 2018 to 5 March 2022.

Methods: We conducted an interrupted time series analysis across three periods: T0 (pre-pandemic: 1 April 2018 to 15 March 2020); T1 (early pandemic: 15 March 2020 to 5 July 2020); and T2 (later pandemic: 6 July 2020 to 5 March 2022).

Results: Pre-pandemic mental health and addiction-related hospitalization rates had significant regional variability, with weekly rates from 6.

Functional difficulties in children and youth with autism spectrum disorder: analysis of the 2019 Canadian Health Survey on Children and Youth.

Introduction: This study examined the prevalence of functional difficulties and associated factors in Canadian children/youth aged 5 to 17 years diagnosed with autism spectrum disorder (ASD).

Methods: We analyzed data from the 2019 Canadian Health Survey on Children and Youth (CHSCY), a nationally representative survey of Canadian children/youth that used the Washington Group Short Set on Functioning (WG-SS) to evaluate functioning in six daily tasks. For each functional domain, binary outcomes were derived (no/some difficulty, a lot of difficulty/no ability).

Multivariate analyses of risk factors associated with laboratory exposure incidents.

Background: Laboratories involved in the study of pathogenic biological agents pose an inherent risk of exposure to the laboratory workforce and the community. Laboratory biosafety and biosecurity activities are fundamental in minimizing the likelihood of unintentional exposure incidents. The objective of this study is to describe the factors that are associated with the occurrence of exposure incidents in a laboratory setting through a predictive model.

Laboratory-acquired infections in Canada from 2016 to 2021.

incidents that result in an exposure to human pathogens and toxins can lead to laboratory-acquired infections or intoxications (LAIs). These infections can pose a risk to the public as well, should person-to-person transmission occur outside the laboratory after an LAI. Understanding factors that contribute to exposure incidents involving LAIs may contribute to ways to mitigate future occurrences to ensure the safety of laboratory workers and the communities in which they work.

Surveillance of laboratory exposures to human pathogens and toxins, Canada, 2021.

Background: The Laboratory Incident Notification Canada surveillance system monitors laboratory incidents that are mandated to be reported under the and the . This article describes laboratory exposure incidents that occurred in Canada in 2021 and individuals affected in these incidents.

Methods: We extracted all laboratory incidents occurring in licensed Canadian laboratories in 2021 from the Laboratory Incident Notification Canada system and analyzed them using the software R.

Impact of school closures and re-openings on COVID-19 transmission.

Background: Globally, the education of students at primary and secondary schools has been severely disrupted by the implementation of school closures to reduce the spread of coronavirus disease 2019 (COVID-19). The effectiveness of school closures in reducing transmission of COVID-19 and the impact of re-opening schools are unclear.

Methods: Research criteria for this rapid review included empirical studies, published or pre-published worldwide before January 25, 2021, that assessed the effectiveness of school closures in reducing the spread of COVID-19 and the impact of school re-openings on COVID-19 transmission.

Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later.

Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS or PIMS), and multiple definitions have been established for this condition that share overlapping features with Kawasaki Disease and toxic shock syndrome.

Methods: A review was conducted to identify literature describing the epidemiology of MIS-C, published up until March 9, 2021.

Surveillance of laboratory exposures to human pathogens and toxins, Canada 2020.

Background: The Laboratory Incident Notification Canada surveillance system monitors laboratory incidents reported under the and the . The objective of this report is to describe laboratory exposures that were reported in Canada in 2020 and the individuals who were affected.

Methods: Laboratory incident exposures occurring in licensed Canadian laboratories in 2020 were analyzed.

Epidemiologic and clinical characteristics of multisystem inflammatory syndrome in adults: a rapid review.

Multisystem inflammatory disease in children (MIS-C) is one of the severe presentations of the coronavirus disease 2019 (COVID-19) that has been described in the literature since the beginning of the pandemic. Although MIS-C refers to children, cases with similar clinical characteristics have been recently described in adults. A description of the epidemiologic and clinical characteristics of multisystem inflammatory disease in adults (MIS-A) is a starting point for better knowledge and understanding of this emerging disease.

COVID-19: A case for the collection of race data in Canada and abroad.

Racialized populations have consistently been shown to have poorer health outcomes worldwide. This pattern has become even more prominent in the wake of the coronavirus disease 2019 (COVID-19) pandemic. In countries where race disaggregated data are routinely collected, such as the United States and the United Kingdom, preliminary reports have identified that racialized populations are at a heightened risk of COVID-19 infection and mortality.

Serum antibody response in COVID-19-recovered patients who retested positive.

Background: Research studies comparing antibody response from coronavirus disease 2019 (COVID-19) cases that retested positive (RP) using reverse transcription polymerase chain reaction (RT-PCR) and those who did not retest positive (NRP) were used to investigate a possible relationship between antibody response and retesting status.

Methods: Seven data bases were searched. Research criteria included cohort and case-control studies, carried out worldwide and published before September 9, 2020, that compared the serum antibody levels of hospitalized COVID-19 cases that RP after discharge to those that did NRP.

Assessing the progression of the COVID-19 pandemic in Canada using testing data and time-dependent reproduction numbers.

Objectives: To compare a mathematical tool and time-dependent reproduction number (R) estimates to assess the COVID-19 pandemic progression in a Canadian context.

Methods: Total number of reported cases were plotted against total number of tests for COVID-19 performed over time, with and without smoothing, for Canada and some Canadian provinces individually. Changes in curvature profile were identified as either convex or concave as indicators of pandemic acceleration or deceleration, respectively.

Correction to: Assessment of stigma in patients with cystic fibrosis.

An amendment to this paper has been published and can be accessed via the original article.

Correlates of former smoking in patients with cerebrovascular disease: a cross-sectional study.

Objective: To identify multilevel correlates of former smoking in patients with cerebrovascular disease.

Design: Secondary data analysis of the Canadian Community Health Survey.

Methods: We used data from the 2007-2008 Canadian Community Health Survey (CCHS).

Assessment of stigma in patients with cystic fibrosis.

Background: Research that explores stigma in Cystic Fibrosis (CF) is limited. Productive cough, repeated lung infections, and periods of serious illness requiring hospitalizations are among common symptoms of CF. These symptoms may cause a negative perception by others.

The prognostic effect of cigarette smoking on stroke severity, disability, length of stay in hospital, and mortality in a cohort with cerebrovascular disease.

Objective: The aim of this study was to determine the prognostic influence of cigarette smoking on stroke severity, disability, length of stay (LOS) in hospital, and mortality in different stroke types.

Methods: A cohort separated by smoking status from the Registry of the Canadian Stroke Network was analyzed using logistic regression while controlling for key outcomes and clinical and demographic characteristics.

Results: There were 20,523 patients that were included for this study from July 2003 to March 2008.

The effectiveness of smoking cessation interventions in smokers with cerebrovascular disease: a systematic review.

Objective: The main objective of this study was to determine the effectiveness of smoking cessation interventions (SCIs) for increasing cessation rates in smokers with cerebrovascular disease.

Design: Systematic review. Two independent reviewers searched information sources and assessed studies for inclusion/exclusion criteria.

A randomised controlled pilot study of standardised counselling and cost-free pharmacotherapy for smoking cessation among stroke and TIA patients.

Background Tobacco use is a major risk factor for recurrent stroke. The provision of cost-free quit smoking medications has been shown to be efficacious in increasing smoking abstinence in the general population. Objective The objective of this pilot study was to assess the feasibility and obtain preliminary data on the effectiveness of providing cost-free quit smoking pharmacotherapy and counselling to smokers identified in a stroke prevention clinic.