Publications by authors named "Roisin O'Reilly"
Article Synopsis
- Circulating tumor cells (CTCs) are critical for understanding tumor diversity and treatment resistance, but traditional methods often capture low numbers, especially in non-small cell lung cancer (NSCLC).
- This study utilized diagnostic leukapheresis (DLA) on six advanced NSCLC patients to access larger blood volumes and employed a new two-step method to enrich CTCs for analysis.
- The results unveiled 3,363 unique CTC transcriptomes, revealing significant heterogeneity and potential distinct phenotypes, which suggests CTCs can serve as valuable indicators for tumor monitoring and targeted therapies in the future.
Geophysical investigation of a former convent graveyard for conversion to a community centre identified an unrecorded, unmarked burial below a later burial. Archaeological excavation confirmed the presence of skeletonized human remains, considered by police as a possible clandestine burial. Mortuary examination indicated the remains belonged to a mature adult female.
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