Microdiversity of isolates in cases of infective endocarditis: selection of non-synonymous mutations and large deletions is associated with phenotypic modifications.

: Today, infective endocarditis (IE) caused by represents 10% of all IE and is marked by its difficult management and the frequency of relapses. Although the precise reasons for that remain to be elucidated, the evolution of the culprit strain under selective pressure through microdiversification could be, at least in part, involved. : To further study the genetic microdiversity and its possible phenotypic manifestations in IE, we sequenced and compared multiple isolates from the valves, blood culture and joint fluid of five patients who underwent valvular surgery.

Modulated Response of and to Antimicrobial Agents in Polymicrobial Biofilm.

The complexity of biofilms constitutes a therapeutic challenge and the antimicrobial susceptibility of fungal-bacterial biofilms remains poorly studied. The filamentous fungus (Af) and the Gram-negative bacillus (Sm) can form biofilms and can be co-isolated from the airways of cystic fibrosis (CF) patients. We previously developed an biofilm model which highlighted the antibiosis effect of Sm on Af, which was dependent on the bacterial fitness.

Three-dimensional imaging control of osteogenesis induced by minimally invasive corticotomies: Perspectives from a case report.

Corticotomies are now an integral part of the orthodontist's therapeutic arsenal in adult orthodontics. In recent years, the number of publications about different surgical techniques has increased significantly. This shows that practitioners and patients have a common interest.

Interactions of and in an Mixed Biofilm Model: Does the Strain Matter?

(Af) and (Sm) are pathogenic microorganisms, which coexist in the respiratory tract of cystic fibrosis (CF) patients. We recently developed an model of mixed biofilm associating Af ATCC 13073-GFP (Af13073) and Sm ATCC 13637 (Sm13637) and described an antibiosis effect. The present study aim was to assess the antibiosis of Sm on Af using different strains and to analyze the potential synergistic virulence of these strains in an model.

The design and synthesis of novel IBiox N-heterocyclic carbene ligands derived from substituted amino-indanols.

A synthetic route towards a number of novel IBiox N-heterocyclic carbene (NHC) ligands has been developed. The resulting ligands have restricted flexibility and high steric demand. Preliminary studies have shown these ligands to give high levels of asymmetric induction in the copper-free allylic alkylation of cinnamyl bromide.