Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia.

Context: The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia susceptibility by several genome-wide association studies. ZNF804A is brain expressed but of unknown function.

Objective: To investigate whether the identified risk allele at the disease-associated single nucleotide polymorphism rs1344706 is associated with variation in neuropsychological performance in patients and controls.

Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.

Context: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility.

Objective: To investigate whether a potential schizophrenia risk single-nucleotide polymorphism (rs6490121) identified in a recent genome-wide association study negatively influences cognition in patients with schizophrenia and healthy control subjects.

Design: A comparison of both cases and controls grouped according to NOS1 genotype (GG vs AG vs AA) on selected measures of cognition in 2 independent samples.