Publications by authors named "Roine R"
Background: Behavioral therapy has proved effective as rumination therapy. Our objective was to treat rumination patients using multidisciplinary behavioral therapy aimed at reducing ≥2 of the rumination score.
Methods: All patients fulfilled Rome IV criteria for rumination and were referred to speech therapy for psychoeducation, diaphragmatic breathing exercises and guided eating, physiotherapy for exercises to relax the thoracic and abdominal muscles, and consultation with the psychologist and the dietitian.
Article Synopsis
- Inhaled xenon combined with hypothermia was tested on comatose patients who survived out-of-hospital cardiac arrest (OHCA) to see if it could protect gray matter in the brain.
- A study of 110 patients found that those who received inhaled xenon and temperature management showed less reduction in brain gray matter volume, especially in areas like the amygdala and temporal gyrus, compared to those who received only temperature management.
- The results suggest that inhaled xenon can help preserve brain structure in this patient group, highlighting its potential therapeutic benefits.
Article Synopsis
- The study examined the link between heavy alcohol use and young-onset cryptogenic ischemic stroke (CIS) in individuals aged 18-49.
- Patients showed significantly higher rates of heavy drinking compared to stroke-free controls, with 13.7% of CIS patients classified as heavy alcohol users versus 6.7% of controls.
- The findings suggest that heavy alcohol consumption, especially binge drinking, is an independent risk factor for CIS in young men, but not in women.
Article Synopsis
- This study investigates the effects of inhaled xenon on metabolic outcomes in out-of-hospital cardiac arrest survivors receiving targeted temperature management.
- Blood samples showed that increased lactate and decreased branched-chain amino acids (BCAAs) were associated with higher mortality rates at 24 and 72 hours post-arrest.
- The findings suggest that high levels of lactate and alanine, along with low BCAAs and small HDL cholesterol, are linked to negative outcomes, while inhaled xenon did not significantly impact the metabolic profile of patients.
Article Synopsis
- Patients with acute intracerebral hemorrhage who were on factor Xa inhibitors were studied to evaluate the effectiveness of andexanet alfa in reversing hematoma expansion compared to usual care.
- In a clinical trial, 263 patients received andexanet while 267 received standard treatment, focusing on hemostatic efficacy and safety outcomes.
- Results showed that andexanet significantly improved hemostatic efficacy (67% vs. 53%) and substantially reduced anti-factor Xa activity, but also led to more thrombotic events (10.3% vs. 5.6% in usual care).
Article Synopsis
- The study focused on how well physicians and patients agree on the severity of angina symptoms in those with stable coronary artery disease (CAD).
- Results indicated that in about half of the cases, there was agreement between physician and patient-reported scores, but physicians tended to report milder symptoms more often.
- The findings suggest that patient-reported symptoms should be prioritized in treatment decisions, as physicians underestimated symptoms in about one-third of cases.
Health care costs and changes in subjective health-related quality of life among Finnish adolescents referred to secondary psychiatric out-patient services: a one-year follow-up study.
Scand J Child Adolesc Psychiatr Psychol
January 2023
Article Synopsis
- A one-year follow-up study aimed to assess healthcare costs and changes in health-related quality of life (HRQoL) among adolescents with three types of psychiatric disorders: behavioral and emotional, mood, and anxiety disorders.
- The study involved 106 adolescents who filled out an HRQoL questionnaire upon entering psychiatric outpatient clinics and at a follow-up, while comparison was made to a control group of 373 peers.
- Findings showed no significant difference in healthcare costs across the disorder groups, but mood disorder patients experienced a noteworthy improvement in HRQoL, highlighting that healthcare costs do not always correlate with treatment quality.
Article Synopsis
- The study analyzed patient preferences and quality of life regarding follow-up methods for early breast cancer, comparing phone calls with a digital solution (Noona) after primary treatment.
- A total of 142 eligible patients participated in the study, with 40% preferring phone calls, 30% favoring the digital solution, and 30% seeing both as equivalent.
- Results showed no significant differences in health-related quality of life or overall satisfaction, but patients did appreciate the quicker response time associated with the digital method, indicating a potential benefit in including digital solutions in post-treatment surveillance.
Article Synopsis
- Up to 40% of ischemic strokes in young patients are cryptogenic, leading to a study comparing blood pressure profiles between these patients and stroke-free controls.
- The study involved 132 young patients with cryptogenic ischemic strokes and 106 controls, assessing 24-hour ambulatory blood pressure patterns, including day/night variations.
- Results indicated that non-dipping patterns of diastolic blood pressure were linked to cryptogenic ischemic strokes, particularly in patients without a patent foramen ovale, suggesting different underlying causes for strokes in patients with and without this condition.
Article Synopsis
- The study investigates the impact of surveillance for intraductal papillary mucinous neoplasms (IPMNs) on patients' health-related quality of life (HRQoL) and anxiety levels.
- A subgroup of 232 out of 899 patients completed HRQoL and anxiety questionnaires before and three months after follow-up, revealing minimal negative effects on their well-being.
- The findings suggest that regular monitoring of patients with IPMNs is manageable and unlikely to significantly worsen their quality of life or anxiety, even as the number of patients under surveillance rises.
Article Synopsis
- A study was conducted between 2004 and 2009 in Finland to examine the health-related quality of life (HRQoL) impacts of melanoma surgery, particularly focusing on limb edema.
- It involved 169 patients filling out quality of life questionnaires at multiple time points, revealing improvements in emotional functioning over time despite some individuals reporting worse HRQoL due to characteristics like female sex and complications.
- The findings highlight that limb edema is a significant predictor of poorer HRQoL in melanoma patients, affecting mobility and pain levels, regardless of its underlying causes.
Article Synopsis
- The study aimed to compare the effectiveness of brain imaging techniques (DTI, 1H-MRS), serum NSE, and motor scores in predicting poor neurological outcomes in comatose patients after out-of-hospital cardiac arrest.
- Results showed that the predictive accuracy of these methods was not significantly better than the motor score alone, although combining data from multiple methods slightly improved accuracy.
- Ultimately, while there is a small benefit in using advanced imaging together with motor scores and seizures for prediction, the complexity and cost make routine use of DTI/MRS in clinical settings unnecessary.
Article Synopsis
- The study analyzes the costs associated with different breast cancer treatment options over two years for Finnish patients, highlighting variations in expenses tied to surgical methods.
- The research involved measuring health-related quality of life (HRQoL) for 1,065 patients using specialized questionnaires and comparing costs across different treatment groups.
- Findings indicate that while immediate and delayed reconstruction had high costs, they also provided good HRQoL, whereas mastectomy resulted in lower HRQoL and higher costs, suggesting potential benefits in identifying candidates for immediate reconstruction earlier to lower overall treatment expenses.
Article Synopsis
- Asundexian is an oral FXIa inhibitor that may prevent thrombosis without raising bleeding risk, and its role in preventing recurrent stroke is being investigated in a clinical trial.
- The PACIFIC-Stroke trial was a phase 2b study that randomly assigned patients with recent ischaemic stroke to receive different doses of asundexian or a placebo while undergoing antiplatelet therapy.
- The study aimed to measure the effectiveness of asundexian in reducing brain infarcts and recurrent stroke, while also monitoring safety related to bleeding events, and included 1,808 participants from 23 countries.
Article Synopsis
- The study aimed to assess the long-term health-related quality of life (HRQOL), educational achievements, and occupational impacts in 55 childhood patients who experienced ruptured brain arteriovenous malformations (AVMs).
- In the research, questionnaires were sent to patients diagnosed before age 20, measuring HRQOL through the 15D instrument and comparing educational levels against the Finnish population.
- Findings indicated that symptomatic epilepsy significantly lowered HRQOL, while early retirement was reported by 11% of patients, though overall educational levels were largely comparable to their peers.
Article Synopsis
- The study evaluated the correlation between changes in health-related quality of life (HRQoL) measured by the 15D instrument and angina severity graded by the Canadian Cardiovascular Society (CCS) in coronary artery disease patients over 12 months.
- Both instruments showed a moderate correlation (r = 0.33) in assessing the patients' conditions, and this correlation was consistent across different age groups, sexes, and treatment methods.
- The findings suggest that while the CCS may miss some broader benefits or harms of treatment, the 15D might not adequately capture disease-specific symptoms, indicating the need for using both types of instruments together for a comprehensive evaluation.
Article Synopsis
- Stenosing atherosclerosis in coronary and carotid arteries can impact cognitive function, and their surgical treatments (CABG and CEA) may lead to different cognitive outcomes.
- A study involving 100 CABG patients and 44 CEA patients analyzed cognitive changes before and after surgery compared to healthy controls, using neuropsychological assessments.
- Results indicated that CEA patients had worse executive functioning before surgery, but experienced greater postoperative cognitive improvement in executive functions than CABG patients, although CABG patients initially faced more cognitive dysfunction.
Article Synopsis
- Previous research suggests that physical activity (PA) is linked to improved health-related quality of life (HRQoL), but few studies focus on premenopausal women at risk for type 2 diabetes (T2D) during the early post-pregnancy period.
- The study observed 204 high-risk women with a median age of 39 and found that those with obesity had lower PA levels, while past gestational diabetes did not significantly impact PA levels.
- A positive correlation was identified between vigorous physical activity (VPA) and HRQoL, but significant associations were only observed in women without obesity.
Article Synopsis
- A study evaluated the mortality rates of chronic pain patients compared to the general population, revealing a higher risk of death, especially among younger individuals (ages 18-49), with males and females facing mortality rates 2.6 and 2.9 times higher, respectively.
- The analysis involved 1,498 patients over an average follow-up of 10.4 years, during which 296 deaths were recorded; low health-related quality of life (HRQoL) and particularly poor psychosocial health were linked to higher mortality risks.
- The findings emphasize the importance of assessing HRQoL using validated tools like the 15D, as both physical and psychological health issues contribute significantly to increased mortality in chronic
Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults.
J Stroke Cerebrovasc Dis
May 2022
Article Synopsis
- - The study investigated the link between obesity and early-onset cryptogenic ischemic stroke (CIS) in young adults, focusing on how fat distribution and gender might influence this relationship.
- - In a sample of 345 young patients with acute CIS and an equal number of stroke-free controls, the research found a significant association between higher waist-to-hip ratios (WHR) and the risk of CIS, particularly in women.
- - Results indicated that while WHR was a strong independent risk factor for CIS in young adults, other obesity measures like body mass index (BMI) and waist circumference did not show a similar association after controlling for various factors.
Article Synopsis
- Analysed breast reconstruction results are crucial for both patient safety and quality of life, comparing immediate and delayed reconstruction methods.
- The study involved 1,065 breast cancer patients, examining health-related quality of life (HRQoL) across different reconstruction techniques over 24 months.
- Though one-third faced complications, results showed that delayed reconstruction offered better HRQoL at 12 months, while immediate reconstruction improved by 24 months, with no significant differences overall between the two methods.
Article Synopsis
- The study examined how work affects the quality of life of rhinology patients, focusing on respiratory exposures and sick leave.
- About 57% of patients experienced worsened nasal symptoms at work, indicating a link between their job environment and their condition.
- Despite only a minority being exposed to specific irritants, overall symptoms and quality of life were significantly impacted, leading to an average of 7.7 days of sick leave per year due to rhinologic issues.
Article Synopsis
- The study examined the occurrence of postprocedural atrial fibrillation (AF) in patients who underwent patent foramen ovale (PFO) closure following cryptogenic stroke in the REDUCE clinical trial.
- AF was noted in 7.4% of patients, primarily occurring within 45 days post-procedure, with most events being non-serious and resolving within two weeks.
- Older age and larger device size were associated with a higher incidence of AF, while male sex was identified as the sole independent risk factor; however, no impact was found based on the type of occluder used or PFO anatomical features.
Article Synopsis
- The Gore REDUCE trial aimed to objectively assess the effectiveness of patent foramen ovale closure versus medical therapy by using blinded MRI evaluations to track new brain infarcts over two years.
- Results showed that 4.7% of closure patients experienced new clinical strokes compared to 10.7% of those on medication alone, indicating that closure significantly reduces the risk of clinical strokes.
- Despite reduced clinical strokes, silent MRI infarcts were similar in both groups, and overall infarct characteristics (number, volume, location) did not differ between closure and medication-only patients.