The 10-Item Short Form of the German Experiences in Close Relationships Scale (ECR-G-10)-Model Fit, Reliability, and Validity.

The aim of the present work was the development and validation of a short form of the Experiences in Close Relationship Scale (ECR) in German. Three studies were conducted. In study 1, the best items for the short form were selected from the item pool of the original version based on ant colony optimization (ACO), a recently developed probabilistic approach.

The Impact of Social Comparisons More Related to Ability vs. More Related to Opinion on Well-Being: An Instagram Study.

Social networks are gaining widespread popularity, with Instagram currently being the most intensively used network. On these platforms, users are continuously exposed to self-relevant information that fosters social comparisons. A distinction is made between ability-based and opinion-based comparison dimensions.

How photo editing in social media shapes self-perceived attractiveness and self-esteem via self-objectification and physical appearance comparisons.

Background: As photo editing behavior to enhance one?s appearance in photos becomes more and more prevalent on social network sites (SNSs), potential risks are increasingly discussed as well. The purpose of this study is to examine the relationship between photo editing behavior, self-objectification, physical appearance comparisons, self-perceived attractiveness, and self-esteem.

Methods: 403 participants completed self-report questionnaires measuring the aformentioned constructs.

Science vs. Conspiracy Theory about COVID-19: Need for Cognition and Openness to Experience Increased Belief in Conspiracy-Theoretical Postings on Social Media.

In the context of COVID-19 virus containment, there is a lack of acceptance of preventive measures in the population. The present work investigated which factors influence the belief in scientific propositions compared with belief in conspiracy theories. The focus here was on the determinants of conspiracy beliefs in the context of COVID-19 related media content.

Post more! The mediating role of social capital between Instagram use and satisfaction with life.

Since more and more people have begun to use social networking sites (SNSs), research on the use of SNSs is flourishing. This study examines Instagram use and the psychological well-being of the users. It was conducted based on two samples (  = 143 and  = 320) examining the relationship between Instagram use, social capital, and satisfaction with life using online questionnaires.

How Downward and Upward Comparisons on Facebook Influence Grandiose and Vulnerable Narcissists' Self-Esteem-A Priming Study.

Past research showed that social networking sites represent perfect platforms to satisfy narcissistic needs. The present study aimed to investigate how grandiose (GN) and vulnerable narcissism (VN) as well as social comparisons are associated with Facebook activity, which was measured with a self-report on three activity dimensions: Acting, Impressing, and Watching. In addition, the state self-esteem (SSE) was measured with respect to performance, social behavior, and appearance.

The anxious addictive narcissist: The relationship between grandiose and vulnerable narcissism, anxiety symptoms and Facebook Addiction.

Vulnerable narcissism and grandiose narcissism share the core of the narcissistic self but are considered as separate forms of this personality trait. While previous research mainly focused on the mechanisms that connect grandiose narcissism and addictive use of the social platform Facebook, it remained unclear why individuals with enhanced levels of vulnerable narcissism are at risk to develop Facebook Addiction (FA). The present study investigated the links between vulnerable and grandiose narcissism, anxiety symptoms, and FA.

The relationship between narcissism, intensity of Facebook use, Facebook flow and Facebook addiction.

Introduction: The present study investigated mechanisms that may contribute to the enhanced risk of narcissistic individuals to develop Facebook addiction.

Methods: In a sample of 449 Facebook users (age: () = 31.07(9.

Relationships between addictive Facebook use, depressiveness, insomnia, and positive mental health in an inpatient sample: A German longitudinal study.

Background And Aims: Individuals with high level of negative mental health often tend to use the social platform Facebook to escape from daily stress. They are at risk to develop an emotional bond to Facebook linked to a need to stay permanently online. The current work investigated addictive use of Facebook and its conceptual framework in clinical context.

The relationship between daily stress, social support and Facebook Addiction Disorder.

The present study investigated the links between daily stress, social support, Facebook use, and Facebook Addiction Disorder (FAD). Two varieties of social support were considered, according to the communication channel: offline and online. In a sample of 309 Facebook users (age: M(SD) = 23.

Relationships between narcissistic grandiosity, narcissistic vulnerability, regulatory focus, regulatory mode, and life-satisfaction: Data from two surveys.

The present data is reported in the article "Regulatory Focus and Regulatory Mode - Keys to Narcissists' (Lack of) Life Satisfaction?" (Hanke et al., in press) [1]. The two data sets represent answers from two German samples.

The brave blue world: Facebook flow and Facebook Addiction Disorder (FAD).

The present study investigated the relationship between flow experienced when using Facebook (Facebook flow; i.e., experience of intensive enjoyment and pleasure generated by Facebook use due to which the Facebook activity is continued even at high costs of this behavior) and Facebook Addiction Disorder (FAD).

Reduction of PCR-amplifiable DNA by ethylene oxide treatment of forensic consumables.

A reliable method to provide molecular biology products free of contaminating DNA is of forensic interest. Ethylene oxide (EO) treatment has been demonstrated as an effective method in published studies. This study aimed to address some additional experiments that are closer to forensic practice.

Activating somatic FGFR2 mutations in breast cancer.

It is known that FGFR2 gene variations confer a risk for breast cancer. FGFR2 and FGF10, the main ligand of FGFR2, are both overexpressed in 5-10% of breast tumors. In our study, we sequenced the most important coding regions of FGFR2 in somatic tumor tissue of 140 sporadic breast cancer patients and performed MLPA analysis to detect copy number variations in FGFR2 and FGF10.

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.

Mutations in fibroblast growth factor receptor 2 (FGFR2) and its ligand, FGF10, are known to cause lacrimo-auriculo-dento-digital (LADD) syndrome. Multiple gain-of-function mutations in FGF receptors have been implicated in a variety of severe skeletal disorders and in many cancers. We aimed to elucidate the mechanism by which a missense mutation in the tyrosine kinase domain of FGFR2, described in the sporadic case of LADD syndrome, leads to reduced tyrosine kinase activity.

Skewed X inactivation in an X linked nystagmus family resulted from a novel, p.R229G, missense mutation in the FRMD7 gene.

Aims: This study aimed to identify the underlying genetic defect of a large Turkish X linked nystagmus (NYS) family.

Methods: Both Xp11 and Xq26 loci were tested by linkage analysis. The 12 exons and intron-exon junctions of the FRMD7 gene were screened by direct sequencing.

A novel stop mutation truncating critical regions of the cardiac transcription factor NKX2-5 in a large family with autosomal-dominant inherited congenital heart disease.

We report on a familial screen of five female members in three generations affected by an autosomal-dominant inherited atrioventricular (AV) conduction block associated with atrial septal defects (ASD) and other congenital cardiovascular diseases (CCVD), such as pulmonary artery stenosis (PAS), patent foramen ovale (PFO) and ventricular septal defect (VSD). We tested the cardiac transcription factor NKX2-5 which is known to cause CCVD with variable phenotype and penetrance by direct sequencing of the two NKX2-5 coding exons in the index patient and identified a novel heterozygous c.325G> T mutation in exon 1 of the gene.

Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway.

Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by abnormalities in lacrimal and salivary glands, in teeth, and in the distal limbs. Genetic studies have implicated heterozygous mutations in fibroblast growth factor 10 (FGF10) and in FGF receptor 2 (FGFR2) in LADD syndrome. However, it is not clear whether LADD syndrome mutations (LADD mutations) are gain- or loss-of-function mutations.

Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss.

In two large Turkish consanguineous families, a locus for autosomal recessive nonsyndromic hearing loss (ARNSHL) was mapped to chromosome 6p21.3 by genome-wide linkage analysis in an interval overlapping with the loci DFNB53 (COL11A2), DFNB66, and DFNB67. Fine mapping excluded DFNB53 and subsequently homozygous mutations were identified in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene, also named tetraspan membrane protein of hair cell stereocilia (TMHS) gene, which was recently shown to be mutated in the "hurry scurry" mouse and in two DFNB67-linked families from Pakistan.

Mutations in different components of FGF signaling in LADD syndrome.

Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3) in LADD families, and in one further LADD family, we detected a mutation in the gene encoding fibroblast growth factor 10 (FGF10), a known FGFR ligand. These findings increase the spectrum of anomalies associated with abnormal FGF signaling.

[Results of early education of developmentally delayed infants and young children by parents with a clinical rehabilitation program].

Early registration of disturbances in the development of infants was based on neurological examination. Since 1984 exists the possibility of psychological evaluation of infants and children in early childhood in the Department of Paediatrics of the University of Rostock. Parents of children suffering from disturbances of development receive additionally to the concept of physiotherapy an early intervention program to furtherance of children.

Glycosphingolipids in patients with the Rett syndrome.

We have pursued two blind studies on the plasma glycosphingolipids in patients with the Rett syndrome (RS), other disorders and normal individuals from Baltimore, USA, Vienna, Austria, and Rostock, East Germany. We found the presence of an unusual glycosphingolipid in 70% of patients with RS. Approximately 10% of the plasma from patients with other developmental disorders also contained this glycosphingolipid.

A study on the Rett syndrome in the GDR.

Of 44 subjects identified by the screening procedure, 31 were enrolled in the study. Using the modified Vienna Rett score, we divided the patients into three groups: typical the Rett syndrome (RS) (n = 10), incomplete forms of RS (n = 5) and non-RS (n = 16). Genetic investigations were performed in some cases and abnormalities were found in two.

[The prognosis of encephalitis in childhood].

Follow-up examination of 95 former patients who had been suffering from encephalitis in infancy were performed. The coincidence of disturbance of consciousness, pathological-EEG and neurological irritation- and deficiency symptoms proved to be an unfavourable prognosis. These patients are especially handicapped in their concentration and motorial performances.