Open-angle glaucoma and Fuchs dystrophy.

A 62-year-old woman with a history of moderate myopia, long-standing open-angle glaucoma (OAG), and Fuchs dystrophy in both eyes was referred for consultative care. She had prior trabeculectomy in 1984 and 1992 in the left and right eyes, respectively. She is 3 months post-Descemet-stripping endothelial keratoplasty (DSEK) in the left eye, now referred with uncontrolled intraocular pressure (IOP) despite maximum tolerated medical therapy.

Comparison of the Icare rebound tonometry with the Goldmann applanation tonometry in a pediatric population.

We report the results of a comparative study at a single center on 214 eyes of 109 pediatric patients in whom IOP was measured using the Icare rebound tonometer and Goldmann applanation tonometry. Measurements from the two modalities demonstrated a correlation coefficient of 0.83 (P < 0.

Effect of topical loteprednol on intraocular pressure after selective laser trabeculoplasty for open-angle glaucoma.

Introduction: To determine whether there is a statistically significant difference in the decrease in intraocular pressure (IOP) after selective laser trabeculoplasty (SLT) between patients receiving a 5-7 days co-administration of loteprednol versus no loteprednol over the course of 1 year.

Methods: We conducted a retrospective chart review to evaluate use of loteprednol in patients aged 30-85 years undergoing SLT for open-angle glaucoma at our center over a 3-year period.

Results: Three hundred and eighteen eyes from 313 patients who underwent a 360° SLT treatment between January 2008 and August 2011 were included in the analysis.

Wet-chemical green synthesis of L-lysine amino acid stabilized biocompatible iron-oxide magnetic nanoparticles.

In this paper, we report a novel method for the synthesis of L-Lysine (lys) amino acid coated maghemite (gamma-Fe2O3) magnetic nanoparticles (MNPs). The facile and cost effective method permitted preparation of the high-quality superparamagnetic gamma-Fe2O3 MNPs with hydrophilic and biocompatible nature. For this work, first we synthesized magnetite phase Fe3O4/lys by wet chemical method and oxidized to y-Fe2O3 in controlled oxidizing environment, as evidenced by XRD and VSM magnetometry.

Fabrication of a glucose biosensor based on citric acid assisted cobalt ferrite magnetic nanoparticles.

A novel and practical glucose biosensor was fabricated with immobilization of Glucose oxidase (GOx) enzyme on the surface of citric acid (CA) assisted cobalt ferrite (CF) magnetic nanoparticles (MNPs). This innovative sensor was constructed with glassy carbon electrode which is represented as (GOx)/CA-CF/(GCE). An explicit high negative zeta potential value (-22.

Comparing the efficacy of the monocular trial treatment paradigm with multiple measurements of intraocular pressure before and after treatment initiation in primary open-angle glaucoma.

The monocular trial has been proposed as a test to help control for diurnal fluctuations in eye pressure when assessing medication effectiveness. We undertook a prospective study to determine the sensitivity and specificity of the monocular trial as a test for determining the effectiveness of a glaucoma medication. The efficacy of the monocular trial was compared to the diagnostic paradigm of repeated pre- and post-treatment measurements in determining whether an intraocular pressure (IOP)-lowering drug is effective.

Evaluation of tensile strength of tissue adhesives and sutures for clear corneal incisions using porcine and bovine eyes, with a novel standardized testing platform.

Background: Tissue adhesives for ophthalmologic applications were proposed almost 50 years ago, yet to date no adequate tissue glues have been identified that combine strong sealing properties with adequate safety and absence of postsurgical side effects. In recent years, cataract surgeries and Descemet's stripping with endothelial keratoplasty procedures have significantly increased the number of clear corneal incisions performed. One of the obstacles to discovery and development of novel tissue adhesives has been the result of nonstandardized testing of potential tissue glues.

Interaction of ocular hypotensive agents (PGF2 alpha analogs-bimatoprost, latanoprost, and travoprost) with MDR efflux pumps on the rabbit cornea.

Purpose: The objectives of this work were (i) to screen ocular hypotensive prostaglandin (PGF2 alpha) analogs--bimatoprost, latanoprost, and travoprost as well as their free acid forms--for interaction with efflux pumps on the cornea and (ii) to assess the modulation of efflux upon co-administration of these prostaglandin analogs.

Methods: Cultured rabbit primary corneal epithelial cells (rPCEC) were employed as an in vitro model for rabbit cornea. Transporter-specific interaction studies were carried out using Madin-Darby canine kidney (MDCK) cells overexpressing MDR1, MRP1, MRP2, MRP5, and BCRP.

Resident laser in situ keratomileusis surgical training in United States residency programs.

To determine current trends in resident laser in situ keratomileusis (LASIK) training in the United States, a comprehensive survey was sent to the residency coordinator, chairman, or refractive surgery director of all 113 ophthalmology training programs in the U.S. accredited by the Accreditation Council for Graduate Medical Education.

Comparison of Proview phosphene tonometry with Goldmann applanation tonometry.

Background: To compare intraocular pressures obtained using a handheld pressure phosphene tonometer (PPT) (Proview, Bausch & Lomb Pharmaceuticals, Inc., Tampa, Fla.) with Goldmann applanation tonometry.

Resident glaucoma surgical training in United States residency programs.

Purpose: To determine current trends in resident glaucoma surgical training throughout the United States.

Methods: A comprehensive survey was sent to the residency director of all 121 ACGME-accredited ophthalmology training programs in the United States.

Results: The mean and median number of glaucoma procedures a resident will complete by the end of their training is 8.

Sudden bilateral visual loss in a diabetic man.

This is a report of a case of the development of acute bilateral cataracts in a diabetic patient. A 28-year-old man presented to the emergency room with a 4-day history of acutely diminished vision. The patient had a recent history of hyperglycemia.

Resident cataract surgical training in United States residency programs.

A comprehensive survey was sent to the residency directors of 129 ophthalmology training programs in the United States. Forty percent of residents gained experience as primary surgeon during their first year; 43% performed only part of the surgery. Seventy-three percent began learning cataract extraction using the extracapsular cataract extraction (ECCE) technique, 24% began with phacoemulsification, and 2% began with either method.

Surgical management of a dysfunctional filtering bleb.

This case report presents a patient who developed a large overhanging bleb following antimetabolite trabeculectomy surgery 6 years prior. Complaints included decreasing vision and foreign body sensation for several months. Successful excisional surgery with placement of compression sutures was performed.

Implantation of second glaucoma drainage devices after failure of primary devices.

Background And Objective: To evaluate the efficacy and safety of implantation of a second glaucoma drainage device for eyes that have failed a primary device.

Patients And Methods: Medical records of patients receiving a primary glaucoma drainage device at Bascom Palmer Eye Institute from January 1987 to October 1998 were reviewed, of which 18 eyes of 18 patients were studied. Patients failing a primary glaucoma drainage procedure and receiving a second glaucoma drainage device were included in this study.