Publications by authors named "Rohini S Ople"
Article Synopsis
- Oxa-iboga compounds are newly developed analogs of ibogaine, designed to retain therapeutic benefits while eliminating cardiac safety risks.
- These compounds demonstrate effectiveness in reducing opioid intake and withdrawal symptoms in animal models, outperforming traditional treatments.
- Oxa-noribogaine specifically acts as a kappa opioid receptor agonist, offering a unique approach to treating substance use disorders with potential for long-lasting effects.
The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse effects, such as respiratory depression and physical dependence, necessitate the development of alternative treatments. Recently we reported a novel strategy to design functionally selective opioids by targeting the sodium binding allosteric site in μOR with a supraspinally active analgesic named .
View Article and Find Full Text PDFA novel and convenient method utilizing the Aubé reaction to access a new class of compounds that are similar to carbocyclic nucleosides is reported. The azido alcohol derived from Vince lactam undergoes the Aubé reaction with various cyclic ketones to give cyclopentenyl-substituted lactams. Upon dihydroxylation, this affords the N-cyclopentenyl-lactam compounds in racemic form.
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