HGF/MET in osteogenic differentiation of primary human palatal periosteum-derived mesenchymal stem cells.

Purpose: This study aimed to determine expressions of hepatocyte growth factor (HGF) and MET proto-oncogene receptor tyrosine kinase (MET) in palatal periosteum (PP) and to examine the effect of HGF/MET on osteogenic differentiation of human palatal periosteum-derived mesenchymal stem cells (PD-MSCs).

Methods: HGF/MET proteins in human palatal periosteum (n = 3) were localized using immunohistochemistry. PD-MSCs (n = 3) were cultured in serum-free Essential 8 (E8) medium or osteogenic medium with and without Capmatinib, a selective ATP-inhibitor of MET.

Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges.

Oral epithelial dysplasia is a spectrum of architectural and cytological epithelial changes caused by accumulation of genetic changes, and is associated with an increased risk of progression to squamous cell carcinoma. It is a microscopic diagnosis of immense clinical importance. The initial reports of oral potentially malignant disorders with oral epithelial dysplasia transforming to oral cancer helped in understanding the nature of oral malignancies.

Multicentre prospective evaluation of implant-assisted mandibular removable partial dentures: surgical and prosthodontic outcomes.

Objective: To determine implant survival and prosthodontic maintenance of implant-assisted mandibular removable partial dentures in a multicentre prospective study up to 10 years.

Materials And Methods: Forty-eight participants with mandibular distal extension partial dentures were selected. A control group of 12 New Zealand participants had new conventional mandibular partial dentures made.

Maxillary Three-Implant Overdentures Opposing Mandibular Two-Implant Overdentures: 10-Year Surgical Outcomes of a Randomized Controlled Trial.

Background: The surgical placement of four maxillary implants for overdentures may not be obligatory when opposing mandibular two-implant overdentures.

Purpose: To determine 10-year surgical outcomes and implant success of three narrow diameter implants in edentulous maxillae with conventional loading.

Materials And Methods: Forty participants with mandibular two-implant overdentures were randomly allocated for surgery for maxillary overdentures.

The thickness of parietal bones in a new zealand sample of cadaveric skulls in relation to calvarial bone graft.

Objectives To evaluate the average thickness of the parietal bones in their different regions to identify the ideal site(s) for calvarial bone graft harvest. Methods and Materials Thickness of the parietal bones of 25 wet cranial vaults of New Zealand European origin was measured in 135 different locations using an electronic caliper. Analyses to identify the ideal harvest sites were conducted so that the sites fit the features of an ideal harvest site described in the literature as: (1) 6 mm of minimum thickness and (2) 2 cm away from the midline.

Trabecular bone microarchitecture in the median palate and maxillary premolar alveolar sites of edentulous elderly cadavers.

Purpose: The median palate has been proposed as an alternative site for implant placement supporting maxillary overdentures. The aim of our research was to compare the histologic bone microarchitecture of the median palatal and the maxillary premolar alveolar ridge in edentulous elderly human cadavers.

Materials And Methods: The bone quality and quantity were analyzed at two regions of analysis (ROA) in 16 maxilla of human cadavers: the median palate (ROA I) and edentulous maxillary alveolar premolar ridge (ROA II).

Soft and Hard Tissue Response to Zirconia versus Titanium One-Piece Implants Placed in Alveolar and Palatal Sites: A Randomized Control Trial.

Background: Titanium (Ti) implants have been used in the last four decades to replace missing teeth. Alternatives to Ti such as zirconia (Zr) may offer aesthetic advantages and be more acceptable to patients and clinicians concerned about Ti allergy but must show equivalent biological acceptability to Ti.

Purpose: The research aimed to investigate soft and hard tissue response to Ti and Zr implants in edentulous patients.

The prognostic accuracy of resonance frequency analysis in predicting failure risk of immediately restored implants.

Objectives: It is of imperative clinical significance to define a safe threshold for planned immediate implant restoration. The aim of this report was to evaluate the prognostic accuracy of resonance frequency analysis (RFA) measurements recorded at two different times (implant placement and 8-week post-implant placement) and to determine the optimal threshold value for predicting failure risk of immediately restored/loaded implants.

Material And Methods: Twenty-eight 8- or 9-mm-diameter implants were placed in either a fresh molar extraction socket or a healed site.

Could the median-palate accommodate wide-bodied implants in order to support maxillary over-dentures? A radiomorphometric study of human cadavers.

Introduction: Atrophy of the alveolar bone is an irreversible multifactorial phenomenon, the rate of which varies between individuals and between the jaws. This atrophy of the alveolar ridges presents severe limitations for the oral rehabilitation of the edentulous patients and poses a clinical challenge to the prosthodontists and implant surgeons. The present research aimed to investigate whether the median-palate of elderly edentulous subjects is anatomically suitable for implant placement.

Facial attractiveness of skeletal Class II patients before and after mandibular advancement surgery as perceived by people with different backgrounds.

The purpose of this study was to determine the perceived level of improvement in facial attractiveness as assessed by people with different backgrounds in skeletal Class II patients treated by mandibular advancement with bilateral sagittal split osteotomy (BSSO). The frontal and lateral pre- and post-operative photographs of 10 Caucasian patients were selected. Changes in frontal and profile attractiveness were assessed by 10 orthodontists, 10 art students, and 10 laypersons.

A nine-year review of orthognathic surgery at the University of Otago.

Objective: To describe the demographic characteristics of patients undergoing orthognathic surgery at the University of Otago over a nine-year period.

Methods: The case notes of patients who underwent orthognathic surgery procedures at the University of Otago from 2001 to 2009 were reviewed retrospectively. This was augmented with a brief literature review of surgical considerations and complications in orthognathic surgery among older patients.

A case series of odontogenic keratocysts from a New Zealand population over a 20-year period.

Purpose: To report on the clinicopathological aspects of odontogenic keratocysts (OKC)/keratocystic odontogenic tumours (KCOT) presenting in a New Zealand population.

Methods: Information on defined areas--including age at presentation, gender, anatomical sub-location, presenting features, histological subtype and the recurrence pattern--were extracted from the histopathological data available in the Oral Pathology database of the University of Otago School of Dentistry.

Results: Two hundred and twenty three cases of OKC/ KCOT were identified over the period ranging from 1987 to 2008.

Immediate single implant restorations in mandibular molar extraction sockets: a controlled clinical trial.

Background: In the replacement of missing teeth, a paradigm shift is currently observed with immediate implant placement and/or restoration, particularly in the aesthetic zone. In molar sites, however, anatomical, occlusal and biomechanical considerations remain deterrent factors influencing the outcome of this treatment paradigm. The aim of this report was to evaluate immediate placement and immediate restoration of strongly tapered wide-diameter implant in fresh mandibular molar extraction sockets.

Fractured zirconia implants and related implant designs: scanning electron microscopy analysis.

Objectives: Two fractured one-piece experimental (commercially unavailable) zirconia implants were analyzed using scanning electron microscope (SEM) analysis to identify failure origins and aid in understanding the failure mechanisms. Modifications to the zirconia implant design are suggested to minimize such fracture incidences.

Materials And Methods: Two zirconia implants fractured during the final torquing in the maxillary ridge using the prescribed hand torque wrench.

Influence of a pedicle flap design on acute postoperative sequelae after lower third molar removal.

Pain, swelling, trismus, and alveolar osteitis often occur after removal of impacted third molar teeth. To minimize these complications a number of mucoperiosteal flap designs have been advocated, but, to date, a pedicle flap design has not been evaluated. In a randomized prospective split mouth study, 52 participants had bilateral symmetrically impacted mandibular third molars removed over two sessions.

Titanium allergy: could it affect dental implant integration?

Purpose: Degradation products of metallic biomaterials including titanium may result in metal hypersensitivity reaction. Hypersensitivity to biomaterials is often described in terms of vague pain, skin rashes, fatigue and malaise and in some cases implant loss. Recently, titanium hypersensitivity has been suggested as one of the factors responsible for implant failure.

Mandibular single-implant overdentures: preliminary results of a randomised-control trial on early loading with different implant diameters and attachment systems.

Objectives: To determine surgical and prosthodontic outcomes of mandibular single-implant overdentures, opposing complete maxillary dentures, using a wide diameter implant and large ball attachment system compared with different regular diameter implants with standard attachment systems.

Materials And Methods: Thirty-six edentulous participants (mean age 68 years, SD 9.2) were randomly assigned into three treatment groups (n=12).

Immediate placement or immediate restoration/loading of single implants for molar tooth replacement: a systematic review and meta-analysis.

Purpose: This systematic review and meta-analysis assessed the survival of immediately placed single implants in fresh molar extraction sites and immediately restored/loaded single molar implants in healed molar sites.

Materials And Methods: A search of the main electronic databases, including the Cochrane Oral Health Group's Trials Register, was conducted up to November 1, 2008. The meta-analysis was prepared in accordance with the guidelines of the Academy of Osseointegration Workshop on the State of the Science on Implant Dentistry.

Primary stability measurements of single implants in the midline of the edentulous mandible for overdentures.

Objectives: To determine the primary stability of the Southern wide diameter (8 mm) implants, Neoss regular diameter (4 mm) implants, and Southern regular diameter (3.75 mm) implants placed in the midline of edentulous mandibles for single-implant overdentures. Variables related to host site and implant characteristics were investigated to determine their influence on the primary stability of the implants.

Mandibular single-implant overdentures: a review with surgical and prosthodontic perspectives of a novel approach.

Objectives: To review the literature on mandibular single-implant overdentures (opposing complete maxillary dentures), and present surgical and prosthodontic perspectives of a novel approach for this treatment option.

Material And Methods: An electronic search through the databases of Pubmed, Embase and Medline using the linked key words 'mandibular single implant overdentures' was performed. The search was limited to English language articles published up to August 2008.

Immediately restored, single-tapered implants in the anterior maxilla: prosthodontic and aesthetic outcomes after 1 year.

Background: Conventional implant protocols advocate a two-stage technique with a load-free, submerged healing period. Recent studies suggest that immediate restoration of single implants may be a viable treatment option.

Purpose: The purpose of this study was to evaluate prosthodontic and aesthetic peri-implant mucosal outcomes of immediately restored, Southern single-tapered implants in the anterior maxilla after 1 year.