Publications by authors named "Rohan Bhardwaj"

Article Synopsis
  • The study identifies 169,197 fusion transcripts in various plant species, suggesting that these transcripts contribute to physiological processes beyond cancer, including stress responses and morphological traits.
  • By analyzing various datasets, the researchers confirm the active translation of some fusion transcripts and explore how DNA sequence organization and chromatin structure influence their formation.
  • The findings indicate that a large number of fusion events result from alternative splicing and that genes located near each other are more likely to fuse, with many fusion transcripts not being translated into proteins.
View Article and Find Full Text PDF

Gene regulation in eukaryotes is partly shaped by the 3D organization of chromatin within the cell nucleus. Distal interactions between -regulatory elements and their target genes are widespread, and many causal loci underlying heritable agricultural traits have been mapped to distal non-coding elements. The biology underlying chromatin loop formation in plants is poorly understood.

View Article and Find Full Text PDF

Unlabelled: Specific endonucleolytic cleavage of tRNA molecules leads to the biogenesis of heterogeneously sized fragments called tRNA-derived non-coding RNAs (tncRNAs). The role of tncRNAs is well studied in human processes, and diseases including different types of cancers and other ailments. They are also generated under stress conditions in plants.

View Article and Find Full Text PDF

In the last three decades, the multi-subunit Mediator complex has emerged as the key component of transcriptional regulation of eukaryotic gene expression. Although there were initial hiccups, recent advancements in bioinformatics tools contributed significantly to prediction and characterization of Mediator subunits from several organisms belonging to different eukaryotic kingdoms. In this study, we have developed the first database of Mediator proteins named MedProDB with 33,971 Mediator protein entries.

View Article and Find Full Text PDF