Combination therapy profoundly improved skin flap survival by modulating KATP channels and nitric oxide.

Purpose: A potential therapeutic approach on skin flap necrosis is to target parallel pathways involved in necrosis. Azelaic Acid, Minoxidil and Caffeine combination was tried on skin flap survival by their possible interaction with ATP sensitive potassium (KATP) channels and nitric oxide pathway.

Material And Methods: Sprauge-Dawley rats were divided into 8 groups for skin flap surgery.