Aim: To assess the efficacy and tolerance of certolizumab pegol (CP) in patients with Crohn's disease (CD) treated in the Department of inflammatory bowel diseases of the A.S. Loginov Moscow Clinical Research Center and to determine the predictors of response to therapy.
View Article and Find Full Text PDFEksp Klin Gastroenterol
December 2013
Our own results of two-stage research are presented in the article. The first stage contains the retrospective analysis of 3682 X-ray examining of large bowel which were conducted in 2002-2004 to define the structure of colon disease and to determine gender differences. The second stage is prospective research which took place from 2003 to 2012 and 486 patients with diverticular disease were regularly observed.
View Article and Find Full Text PDFExcessive poorly differentiated epitheliocytes were detected in the crypts and subepithelial regions of the colorectal mucosa during the regeneration process in the majority of patients with diverticular disease. The compensatory reaction of the sigmoid mucosa decreased, which was seen from rarely detected cryptic hyperplasia. Disorders in the epitheliocyte proliferation and differentiation were paralleled by changes in tissue levels of proinflammatory cytokines (elevation of TNF-α and IFN-γ and reduction of IL-1β and IL-8) and increase of IL-4, regulating lymphocyte activation.
View Article and Find Full Text PDFThis article presents the results of a study of respiratory function (SRF) in 56 patients with Crohn's disease (CD) who were hospitalized in the Department of intestine pathology in Central research institute of gastroenterology. SRF was determined by spirography and registration of the curve flow--volume forced exhale ("Eton-1, RF). Violations of pulmonary function in CD occurred in 44.
View Article and Find Full Text PDFAim: To determine the role of immune response with production of auto- and heterologous antibodies (Ab) in development of the pathological process and in structural changes in colon mucosa (CM) in diverticulosis (Dv).
Material And Methods: Of 219 Dv patients, 39 were newly diagnosed with x-ray-detected signs of previous inflammation (group 1), 180 had earlier detected Dv which was confirmed and endoscopic examination detected inflammation (group 2). The comparison group consisted of 25 patients with irritable colon syndrome.
The first results of allogeneic mesenchymal stem cells from the bone marrow transplantation to patients with ulcerative colitis demonstrated improved clinical course. We found an increasing in the duration of remission in patients with chronic recurrent and continuous recurrent course of ulcerative colitis. Also it was noted reducing the risk of relapse, and reducing the frequency of hospital admissions compared with medication therapy with only 5 aminosalicylic acid and glucocorticosteroid.
View Article and Find Full Text PDFAim: to determine the whether mesenchymal stem cells (MSC) may be used in the treatment of patients with chrOnic intestinal inflammatory diseases (IID).
Subjects And Methods: Thirty-nine patients with ulcerative colitis (UC) (Group 1) and 11 with Crohn's disease (CD) (Group 2) were examined. Comparative groups included 30 patients with UC (Group 2) and 10 with CD (Group 4).
Eksp Klin Gastroenterol
June 2011
This article presents a comparative analysis of the frequency and types of violations of respiratory function (RF) in ulcerative colitis (UC) in 29 elderly patients and in 108 patients younger than 60 years. Pulmonary function was studied by spirometry and record the flow curve--forced expiratory volume ("Eton-1"). Prescribe a higher rate of airflow obstruction in older compared with patients younger than 60 years (from 65.
View Article and Find Full Text PDFUnlabelled: The aim of the study was to determine the efficacy and safety of mesenchymal stromal cells (MSCs) of bone marrow in the treatment of patients with ulcerative colitis (UC).
Materials And Methods: The study included 44 patients with ulcerative colitis (UC), which was implemented MSC transplantation, 40 patients with UC who received standard therapy with mesalazane (salofalka) 4-6 g/day and corticosteroids (prednisone)--1-2 mg/kg, azathioprine--1.5 mg/kg methotrexate 20-50 mg/m2, and 12 patients who underwent induction and maintenance of infliximab therapy.
Systemic transplantation of mesenchymal stem cells (MSC) is known to promote reparative process in a number of tissue damage as well as mucous healing one. It provided the basis for our study which was aimed to the effect of systemic transplantation of allogenic MSC (intravenous transfusion) in complex therapy of patients with Ulcerative Colitis.
View Article and Find Full Text PDFEksp Klin Gastroenterol
January 2006
The treatment of ulcerous colitis and Crohn's disease is based on suppression of various components of the immunoinflammatory cascade. In addition to aminosalicylates and glucocorticoids, drugs of primary immunosuppressive action are used for this purpose, which are adopted from clinical oncology and transplantation medicine: azathioprine, 6-mercaptopurine, methotrexate, cyclosporine A, tacrolimus, mycophenolate mofetil, thalidomide. Some of them are used for remission induction in case of hormonal dependence or resistance, while others are applied for its maintenance or at various stages of the inflammatory process course.
View Article and Find Full Text PDFThe article presents a study of clinical variants of ischemic lesions of the large intestine (ILLI) in patients with the chronic abdominal ischemia (CAI) syndrome. There was an examination of 42 patients with putative ILLI, who had a cardiovascular pathology at the background, which led to significant hemodynamic disorders of the blood flow in unpaired visceral branches of the abdominal aorta. The authors performed a complex diagnostics of ILLI including anamnestic and clinical data, laboratory and morphological assessment of the large intestine and vessels providing its blood supply.
View Article and Find Full Text PDFEksp Klin Gastroenterol
May 2003
This research testifies to the fact that it is more preferable to use mesacol than sulfasalazine in treatment of common forms of ulcerative colitis of light and average severity. Mesacol acts faster in arresting inflammations in proximal parts of the larger intestine. One can assume that the pH-dependent release of 5-aminosalicylic acid in these forms of the disease suffers less than the destruction of the diazo link by the anaerobic microflora, due to which a higher concentration of the preparation is formed in the large intestine.
View Article and Find Full Text PDFHemorrhoids is believed by right to be one of the most widely spread human sufferings ranking first among diseases of the rectum and large intestine. According to the data of numerous studies devoted to this problem, from 2.9 to 27.
View Article and Find Full Text PDFHemostatic disorders are involved in the pathogenesis of inflammatory large intestine diseases. Both thrombocytes and humoral coagulation factors are involved in this process. An attempt to correct these disorders will allow not only to declare a new approach to the treatment of inflammatory large intestine diseases but also to clarify their role in the occurrence and persistence of an active inflammation during these diseases.
View Article and Find Full Text PDFEksp Klin Gastroenterol
July 2002
Colon absorption function was examined in twenty fife patients with active non-specific ulcerative colitis (15 persons with the distal form and 10 with left-side form investigate by rectal antipyrin test. The state of absorption was estimated on duration of antipyrin half-absorption, on attainment of its maximal concentration and on level of its salivary concentration. Most of patients (n = 19) with active non-specific ulcerative colitis had disorders of colon absorption.
View Article and Find Full Text PDFEndoscopic biopsies were carried out in 62 patients with colon villous adenomas and 28 patients with colon adenocarcinomas. Differential-diagnostic schemes of evaluation different morphological versions of colon villous adenomas were used for processing results of hystological investigations. These schemes were offered by G.
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