[Sarcoidosis with Cardiac Involvement and Monoclonal Gammopathy].

The article presented a clinical case of 8-year follow-up of a patient with a relatively beneficial course of pulmonary sarcoidosis and intrathoracic lymph nodes and with gradually progressing myocardial injury. A specific feature of the case was that the patient had monoclonal gammopathy, which is extremely rarely reported. Morphological signs of paraproteinemic hemoblastosis and amyloidosis were not observed.

[Renal and uterine hemodynamics in pregnancy with chronic glomerulonephritis of the hypertonic type].

Aim: To study gestational changes in renal and uterine hemodynamics and their relation to systemic and intracardiac hemodynamics in pregnant hypertensive women with chronic glomerulonephritis (CGN).

Material And Methods: Echocardiography, ultrasonic dopplerography of renal and uterine arteries were made in 16 pregnant women with CGN and AH syndrome in trimester II-III and 1-3 months after the delivery. Hemodynamic indices in pregnancy were compared to those after the delivery which were considered baseline.

[Diagnostic differentiation between two syndromes of progressive myoclonus epilepsy].

The study aimed to differentiate, according to clinical and electroencephalographical criteria, between the most frequent types of myoclonus epilepsy--Unverricht-Lundborg disease (ULD) and Lafora disease (LD). Two patients with ULD and two with LD, aged 13-16 years, have been examined. In all cases, the diagnosis of myoclonus epilepsy has been verified by using molecular genetic analysis.

[Renal and uterine hemodynamics in pregnant women with hypertension].

Aim: To study gestational alterations of renal and uterine hemodynamics, their relationships with systemic and intracardiac hemodynamics in pregnant women (PW) with essential hypertension (EH).

Material And Methods: Echocardiography, ultrasound dopplerography of renal and uterine arteries, roll-over test were made in the course of trimester II-III and 3 months after the delivery in 48 PW with EH degree 1-2 and control 20 healthy PW. Hemodynamic parameters in pregnancy were compared to postpartum ones.

[Basic pathogenetic mechanisms of chronic placental insufficiency].

Six basic mechanisms facilitating development of chronic placental deficiency, hypotrophy and fetal death are distinguished: 1) insufficiency of invasion of the extra-villous cytotrophoblast into the placental bed resulting in incomplete gestational restructuring of spiral arteries and reduction of uteroplacental circulation; 2) rheological disturbances in the intervillous space due to ultrastructural pathology of the glycocalyx and microvilli of the cytiotrophoblast; 3) pathological immaturity of microvilli and retraction of the diffusion surface; 4) disturbances of the villi perfusion resulting from prevailing development of the connective tissue components, reduction of stroma capillary bed and obliteration angiopathy at the level of supporting villi and umbilical cord; 5) placental barrier pathology; 6) endocrine deficiency resulting from the deficiency in the synthesis of human chronic gonadotropin during the first and, in part, second trimesters and the shortage of placental lactogen at the end of pregnancy.

[Functional morphology of the placental bed of the uterus].

The review deals with the literature and authors' data on the structure and function of main components of the uterus placenta bed under normal course of pregnancy. The attention is focused on the most important process, namely, the invasion of non-villous or interstitial cytotrophoblast into the walls of spiral arteries of the endo- and myometrium, their gestational restructuration which ensures sequential increase of the uterus-placenta circulation and, consequently, optimal foetal development. This information is necessary for the understanding of the pathological processes in the zone of uterus-placenta contact.

[Characteristics of postoperative period in surgical treatment of chronic frontal sinusitis].

During the last 5 years 132 patients underwent frontal-ethmoidal trepanation. Recurrences were observed in 27 (20%) patients with nonspecific immune deficiency, frequent respiratory viral infections and microbial virulence. The major cause of recurrences was inadequacy of the frontal-nasal ostium.

[Blood lipophages in patients with ischemic heart disease].

Ninety three individuals were examined and divided into 3 groups: (1) patients with coronary heart disease in the presence of angiographically documented coronary atherosclerosis; (2) those with non-specific aortoarteritis; and (3) subjects without signs of cardiovascular disease. Blood levels of lipid-saturated mononuclear cells were measured by flow cytofluorimetry. The patients (42 (90%) patients of 46) of the first group were found to have higher blood lipophages than those of the other groups, no correlation being established between the plasma content of total cholesterol, high density lipoprotein cholesterol and triglycerides.

[Low density lipoproteins isolated from the blood of patients with ischemic heart disease induce accumulation of lipids in human aortic intima cells].

Very low density lipoproteins (VLDL), low density lipoproteins (LDL) and high density lipoproteins (HDL) were isolated from the blood of healthy subjects and CHD patients. LDL from the blood of healthy individuals did not raise the intracellular lipid values within 24 h of cultivation. During intracellular lipid values within 24 h of cultivation.

[Cholesterol-containing circulating immune complexes--a component of the blood serum in patients with ischemic heart disease that determines its atherogenic properties].

In most patients with coronary heart disease (CHD) and angiographically documented stenosed 1-3 coronary arteries, serum contained cholesterol (C) in the circulating immune complexes (CIC), cholesterol levels in these complexes being directly related to serum atherogenicity, i.e. to their ability to cause a 2-5-fold accumulation of lipids in cultured smooth muscle cells (SMC) of the uninvolved human aortic intima (r = 0.

[Effectiveness of different methods of blood separation in performing plasma- and cytapheresis].

Obtaining of a therapeutic dose of platelets from donors, necessary to stop spontaneous hemorrhage and sufficient enough to correct hemostasis in surgical interventions in patients with amegakaryocytic thrombocytopenia, therapeutic plasmapheresis with the removal of 1.5-2.01 of plasma, effective erythrocytapheresis can be done with the help of refrigerator centrifuges and plastic containers.

[Blood transfusion support in cardiac surgery].

The paper is concerned with experience in transfusion-infusion tactics in 55 patients with coronary heart disease with multiple atherosclerotic involvement of the coronary arteries who underwent aortocoronary bypass surgery. The purpose of transfusion therapy in such patients was to preserve to maximum the patient's own blood (autoblood, etc.), independent correction of blood coagulation factors with antihemophilic plasma and correction of blood oxygen transport function with donor erythrocytic mass without infusion of excessive liquid volumes, postoperative care of patients under the conditions of moderate hypocoagulation and hemodilution.

[Monolayer culture of bone marrow and splenic fibroblasts in lymphoproliferative diseases].

The authors describe the results of monolayer cultivation bone marrow and spleen fibroblasts in patients with lymphoproliferative diseases. The efficacy of colony-formation of fibroblasts (ECFf) was studied in 10 patients with chronic lympholeukemia, 4 with leukemic reticuloendotheliosis, in 5 with lymphocytoma of the spleen, and in 3 with lymphosarcoma of the spleen. The control group comprised 7 normal subjects.