Metabolic responses to bicycle exercise after several days of physical work and energy deficiency.

The responses of plasma free fatty acids (FFA), free glycerol, beta-hydroxybutyrate (BUT) and glucose to bicycle exercise (corresponding to 50% of the maximal VO2) were investigated in 11 cadets of the Norwegian Military Academy, before a combat course (control experiment) and on the third and fifth day of such a course which involved nearly continuous intense military activities and pronounced energy deficiency. Pre-exercise levels of FFA, glycerol and BUT were greatly elevated on days 3 and 5 as compared with pre-exercise levels before the course. The increases in plasma FFA, glucose and BUT in response to bicycle exercise were much more pronounced on days 3 and 5 than before the course.

Immunohistochemical study of secretory component, secretory IgA and carcinoembryonic antigen in large bowel carcinomas.

The epithelium of 41 large bowel carcinomas was scored immunohistochemically on a semiquantitative basis for the presence of secretory component (SC), secretory IgA, and carcinoembryonic antigen (CEA). Both the tumour and the adjacent "transitional mucosa" were evaluated. The various immunofluorescence scores obtained, the histological grades of the tumours, their Dukes' stages, and the plasma CEA levels were subjected to non-parametric correlation analyses.

Altered hormonal response to short-term bicycle exercise in young men after prolonged physical strain, caloric deficit, and sleep deprivation.

The hormonal response to a standardized bicycle exercise test was studied in 11 male cadets exposed to a course of 107 h of continuous activity with less than 2 h sleep. The subjects expended only about 8,600-11,000 kcal/24 h whereas their daily food intake contained only about 1,500 kcal. The exercise test was performed once 12 days before the course (control experiment) and on day 3 and day 5 during the course, always between 0700-0900 h.

Immunohistochemistry of epithelial cell markers in normal and pathological colon mucosa. Comparison of results based on routine formalin- and cold ethanol-fixation methods.

The purpose of this study was to examine whether formal-dehyde-fixed tissue may afford reproducible and reliable immunhistochemical results when carcinoembryonic antigen (CEA), secretory component (SC), and epithelial IgA are evaluated semiquantitatively in normal and pathological colon specimens. Proximate tissue samples were processed by routine formalin fixation and by a cold-ethanol fixation method, respectively, and the immunofluorescence intensities obtained for the three antigens were scored. After formalin fixation SC and epithelial IgA were generally undetectable and also the staining for CEA was markedly reduced compared with that seen after ethanol fixation.

Fat cell size and lipid content of subcutaneous tissue in congenital generalized lipodystrophy.

Fat cell size and lipid composition of subcutaneous tissue from 3 patients with congenital generalized lipodystrophy have been measured before and after treatment with either pimozide, fenfluramine or hypophysectomy. The fat cell volume before treatment ranged between 9.8 x 10(4) and 17.