Neurological Manifestations in Familial Mediterranean Fever: a Genotype-Phenotype Correlation Study.

Background And Aims: Familial Mediterranean Fever (FMF) is a periodic auto-inflammatory disease with an autosomal recessive hereditary pattern. The aim of this study is to explain the spectrum of possible neurological manifestations and its genotype-phenotype correlation in patients with familial Mediterranean fever.

Methods: In this case series study, data of 311 FMF patients at the FMF Registration Center in Iran (http://www.

Kawasaki disease and familial mediterranean fever gene mutations, is there any link?

Kawasaki disease (KD) is an acute febrile, self-limiting, and systemic vasculitis of unknown etiology. MEFV gene has a major role in autoinflammatory disorders and innate immune reactions. Several reports revealed that MEFV gene mutations are associated with systemic vasculitis.

Relapsing periodic arthritis, palindromic rheumatism and MEFV gene-related variants alleles in children.

Background: Relapsing periodic arthritis is a general term used for a group of diseases with recurring and periodic nature, in which the joints are intermittently involved. The aim of this study is to evaluation of the possible relationship between MEFV gene mutations in intermittent arthritis of children which has recurring and periodic nature.

Methods: In this cross-sectional study we reviewed medical records of all patients with recurrent and periodic arthritis referred to pediatric rheumatology clinic from 2003 to 2019.

Familial Mediterranean Fever Gene Mutations and Gout as an Auto-Inflammatory Arthropathy.

Introduction: The auto-inflammatory diseases (AID) are a heterogeneous group of multi-system disorders of innate immunity dysregulation. MEFV gene has major role in AID.

Aim: The aim of this study is to investigate the frequency of MEFV variant alleles in gout patients as an AID and their genotype-phenotype relationship.