Publications by authors named "Roger Sandre"
Article Synopsis
- Many people with HIV struggle to stick to their antiretroviral therapy, leading to potential health risks and increased transmission of the virus.
- The study, TriiADD, aimed to see if switching to a single-tablet regimen (ABC/3TC/DTG) along with personalized support would enhance HIV suppression in non-adherent individuals.
- Although the switch showed a trend towards better outcomes, recruitment issues and adherence measurement challenges posed significant obstacles in completing the trial.
Background: Associations between HIV-related stigma and reduced antiretroviral therapy (ART) adherence are widely established, yet the mechanisms accounting for this relationship are underexplored. There has been less attention to HIV-related stigma and its associations with ART initiation and current ART use. We examined pathways from HIV-related stigma to ART initiation, current ART use, and ART adherence among women living with HIV in Canada.
View Article and Find Full Text PDFData are lacking on factors that may impact conception-related decision-making among individuals living with HIV. This study's aim was to shed light on these considerations. Participants were invited to complete a survey on preconception considerations.
View Article and Find Full Text PDFArticle Synopsis
- - The study evaluates how well the results of clinical trials for direct-acting antivirals (DAAs) against hepatitis C virus (HCV) apply to individuals who are coinfected with HIV, highlighting a gap in understanding their effectiveness for this group.
- - Researchers analyzed five clinical trials and found that only a small percentage of participants from a Canadian cohort were eligible for these trials, suggesting that trial results may not be applicable to the broader population of coinfected patients.
- - Most exclusion criteria in the trials focused on factors like specific antiretroviral therapies and active drug use, raising concerns about the relevance of results for those at higher risk of adherence issues and reinfection—populations that need more real-world data. *
Background: Liver diseases progress faster in human immunodeficiency virus (HIV)-hepatitis C virus (HCV)-coinfected persons than HIV-monoinfected persons. The aim of this study was to compare rates of liver fibrosis progression (measured by the aspartate-to-platelet ratio index [APRI]) among HIV-HCV-coinfected users of modern protease inhibitor (PI)- and nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens with a backbone of tenofovir/emtricitabine (TDF/FTC) or abacavir/lamivudine (ABC/3TC).
Methods: Data from a Canadian multicenter cohort study were analyzed, including 315 HCV polymerase chain reaction-positive persons who initiated antiretroviral therapy with a PI or NNRTI and a backbone containing either TDF/FTC or ABC/3TC.
The Ontario HIV Treatment Network Cohort Study (OCS) is an observational, open dynamic cohort of people who are receiving medical care for human immunodeficiency virus (HIV) infection in Ontario, Canada. Established in the mid-1990s, the OCS has its roots in AIDS activists' demands for research that would improve the quality of life of people living with HIV while respecting their privacy. It is a collaborative and community-driven study, including a Governance Committee made up of people with HIV and other stakeholders that evaluates analysis project proposals for community relevance and ethics.
View Article and Find Full Text PDF