The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice.

We evaluated the efficacy of three dietary interventions started at middle age (14 months) to retard the aging process in mice. These were supplemental alpha-lipoic acid (LA) or coenzyme Q(10) (CQ) and caloric restriction (CR, a positive control). LA and CQ had no impact on longevity or tumor patterns compared with control mice fed the same number of calories, whereas CR increased maximum life span by 13% (p <.

Aging and immunity in nonhuman primates: I. Effects of age and gender on cellular immune function in rhesus monkeys (Macaca mulatta).

Immunity declines with advancing age. Lymphocyte proliferation, natural killer cell activity, and antibody response to tetanus toxoid vaccination were evaluated in cohorts of rhesus monkeys (Macaca mulatta) aged 2-36 years in order to characterize senescent changes in immune function. The results were analyzed in accordance with host age.