Publications by authors named "Roger Compte"
Objective: The chronic pain syndromes (CPS) include syndromes such as chronic widespread pain (CWP), dry eye disease (DED) and irritable bowel syndrome (IBS). Highly prevalent and lacking pathognomonic biomarkers, the CPS are known to cluster in individuals in part due to their genetic overlap, but patient diagnosis can be difficult. The success of quantitative sensory testing (QST) and inflammatory biomarkers as phenotyping tools in conditions such as painful neuropathies warrant their investigation in CPS.
View Article and Find Full Text PDFBackground Context: Associations between magnetic resonance imaging (MRI)-detected lumbar intervertebral disc degeneration (LDD) and LBP are often of modest magnitude. This association may be larger in specific patient subgroups.
Purpose: To examine whether the association between LDD and LBP is modified by underlying genetic predispositions to pain.
Introduction: Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions are thought to manifest local inflammation and if inflammatory proteins translocate to the blood circulation could be detected systemically. The work here assesses whether the presence of disc degeneration is associated with detectable blood level changes of five inflammatory markers and whether chronic LBP is associated with these changes.
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- * A study tracked the stool and saliva microbiomes of newly diagnosed RA patients before and during DMARD treatment to determine if microbiome profiles could predict treatment responses.
- * Results showed that certain gut microbes, particularly Prevotella and Streptococcus, decreased in patients who improved with DMARD therapy, suggesting that microbiome analysis could help identify patients who might not respond well to this treatment.
The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD) necessary for sustaining the nutrition of the disc while distributing mechanical loads and preventing the disc from bulging into the adjacent vertebral body. The size, shape, and composition of the CEP are essential in maintaining its function, and degeneration of the CEP is considered a contributor to early IVD degeneration. In addition, the CEP is implicated in Modic changes, which are often associated with low back pain.
View Article and Find Full Text PDFChronic back pain (CBP) is a complex heritable trait and a major cause of disability worldwide. We developed and validated a genome-wide polygenic risk score (PRS) for CBP using a large-scale GWAS based on UK Biobank participants of European ancestry (N = 265,000). The PRS showed poor overall predictive ability (AUC = 0.
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- * The review aimed to evaluate the effectiveness of machine learning algorithms in identifying conditions like disc degeneration and herniation compared to traditional radiologists' assessments using systematic reviews and meta-analysis.
- * Out of 1350 articles analyzed, 27 studies on ML algorithms showed that, while these algorithms can assess LDD effectively, they performed better in controlled developmental studies than in real-world applications, and using data augmentation improved their capabilities.
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and biochemical changes in intervertebral discs (IVD) that prompt a pathologic shift from an anabolic to catabolic state, affecting extracellular matrix (ECM) production, enzyme generation, cytokine and chemokine production, neurotrophic and angiogenic factor production. The IVD is an immune-privileged organ.
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