Publications by authors named "Roger Cho"
Article Synopsis
- Degenerative Cervical Myelopathy (DCM) is caused by degeneration of the spine, leading to symptoms like balance issues and numbness in the arms and hands.
- The study used machine learning to classify patient data from MRI scans, focusing on spinal canal diameter (SCD) and cord compression patterns to identify groups at higher risk for neurological decline.
- Findings indicate that while severe compression at two disc levels heightens deterioration risk, SCD and compression alone are not reliable predictors of decline; rather, a specific combination of factors is crucial for assessing risk in patients.
Background Context: Degenerative cervical myelopathy (DCM) is the most common form of atraumatic spinal cord injury globally. Degeneration of spinal discs, bony osteophyte growth and ligament pathology results in physical compression of the spinal cord contributing to damage of white matter tracts and grey matter cellular populations. This results in an insidious neurological and functional decline in patients which can lead to paralysis.
View Article and Find Full Text PDFMesenchymal progenitor cells (MPCs) have been recently identified in human and murine epidural fat and have been hypothesized to contribute to the maintenance/repair/regeneration of the dura mater. MPCs can secrete proteoglycan 4 (PRG4/lubricin), and this protein can regulate tissue homeostasis through bio-lubrication and immunomodulatory functions. MPC lineage tracing reporter mice (Hic1) and human epidural fat MPCs were used to determine if PRG4 is expressed by these cells in vivo.
View Article and Find Full Text PDFStudy Design: Retrospective cohort study.
Objective: We evaluated the effectiveness of minimally invasive (MIS) tubular discectomy in comparison to conventional open surgery among patients enrolled in the Canadian Spine Outcomes and Research Network (CSORN).
Methods: We performed an observational analysis of data that was prospectively collected.
Study Design: Uncontrolled retrospective observational study.
Objectives: Surgery for patients with back pain and degenerative disc disease is controversial, and studies to date have yielded conflicting results. We evaluated the effects of lumbar fusion surgery for patients with this indication in the Canadian Spine Outcomes and Research Network (CSORN).
Background Context: Lumbar degenerative stenosis is one of the most common spine pathologies for which surgical intervention is indicated. There is some evidence that a prolonged duration of neurological compression could lead to a failure of surgery to alleviate symptoms.
Purpose: Determination of whether longer symptom duration was associated with worse postoperative disability outcomes after decompressive surgery for lumbar degenerative stenosis.
Study Design: Isolation and characterization of human epidural fat (HEF) stem/progenitor cells.
Objective: To identify a progenitor population within HEF and to determine if they meet the minimal criteria of a mesenchymal stem cell (MSC).
Summary Of Background Data: The biological function, if any, has yet to be determined for HEF.