Publications by authors named "Roger Agyei"
Nonhomologous end joining (NHEJ) is the major DNA double-strand break (DSB) repair pathway in mammalian cells. A critical step in this process is DNA ligation, involving the Xrcc4-DNA ligase IV complex. DNA end processing is often a prerequisite for ligation, but the coordination of these events is poorly understood.
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- Genome instability is a key feature of cancer, and understanding how to prevent it is crucial but not well understood yet.* -
- Researchers identified the Elg1 gene as a significant suppressor of chromosomal rearrangements in budding yeast, which may play a similar role in human cells.* -
- The study shows that Elg1 is essential for proper DNA replication and helps maintain genome stability by interacting with other proteins involved in DNA processing, suggesting its loss leads to increased genome instability.*