[Thickness of the retinal photoreceptor layers and the choroid, and bioelectrical activity of the macula in retinitis pigmentosa].

Purpose: To assess the changes in photoreceptor retinal layers and the choroid in comparison with bioelectrical activity of the macula in patients with retinitis pigmentosa (RP).

Material And Methods: The study included 10 patients (20 phakic eyes) with RP. Mean age was 27±18.

Stargardt disease-associated mutation spectrum of a Russian Federation cohort.

ABCA4-associated mutation screening is extensively performed in European, African, American and several other populations for various retinopathies. However, it has not been well studied in a Russian cohort. Using next-generation (325 genes inherited disease panel) and Sanger sequencing technologies for the first time we documented the spectrum of genetic variations in a Russian retinopathy cohort of 51 patients from 10 ethnic groups.

[Ocular blood flow and retinal electrogenesis in retinitis pigmentosa].

Aim: to investigate correlations between changes in ocular hemodynamics revealed by color Doppler flow mapping (CDFM) and pulsed-wave (PW) Doppler imaging, one the one hand, and electrical activity of the retina, on the other, in patients with early, moderate, and severe retinitis pigmentosa (RP).

Material And Methods: A total of 20 patients (40 eyes) aged from 16 to 40 years (28.4 ± 8.

[Macular and multifocal electroretinography in the diagnosis of Stargardt's dystrophy].

Retinal bioelectrical activity was studied in Stargardt's dystrophy from the data of multifocal and macular electroretinography (M-ERG) and retinal morphometry was carried out. The group of 11 patients (22 eyes) with the central form of Stargardt's dystrophy showed reductions in the retinal density of a bioelectric response of a P1 component, the amplitude of N1 and P1 components in the area of 0 to 16 degrees, as well as decreases in the amplitude of M-ERG a- and b-waves and in the retinal thickness in the macular region. The mixed Stargardt's dystrophy group was characterized by reductions in the retinal density of an electrical response of a P1 component, in the amplitude of N1 and P1 components in the entire posterior pole in the area of 0 to 32 degrees, as well as decreases in the a- and b-waves of M-ERG, photopic, scotopic, and mixed ERG; the lowered retinal thickness was found in the foveal and parafoveal regions.

[Clinical significance of studies of microorganisms of the intestinal mucosa by culture biochemical methods and mass fragmentography].

This research is a continuation of the series of studies of the parietal microbiota of the bowel tissue samplings by the gas chromatography and mass spectrometry (GCMS) method [G.A. Ossipov et al.

[The comparative activity of cefepime and other current antibiotics against microorganisms isolated from patients in pediatric intensive therapy units].

Comparative activity of cefepime, ceftazidime, ceftriaxone, ciprofloxacin, imipenem and piperacillin/tazobactam against isolates from patients of pediatric intensive care units within October-December 1998 was studied. The isolates were identified with the Walkaway-40 System. The antibiotic susceptibility was evaluated by the E-test on the Mueller-Hinton II agar.

[Contrast sensitivity in amblyopia, abiotrophy and optic nerve atrophy in children].

The threshold spatial contrast sensitivity was assessed in children with amblyopia, tapetoretinal abiotrophy, and partial atrophy of the optic nerve of different origin. The measurements were carried out at spatial frequencies of 0.5-22 cycle/grad.

[Gas chromatography in express diagnosis of candidiasis and monitoring of antifungal therapy efficacy by D-arabinitol and mannose levels in pediatric patients].

Seventy three children (40 blood and 43 liquor specimens) were examined with the use of gas chromatography (GC) to detect background concentrations of Candida metabolites. The criterium of the children enrollment to the control group was the absence of the clinical and laboratory signs of the fungal infection. The normal contents of the fungus metabolites were considered to be 0.

[Critical frequency of flashes fusion in differential diagnosis of vision disorders in children].

Critical frequency of fusion of flashes (CFFF) was measured in children by CFFF-D device recommended for clinical trials by the Ministry of Health and Medical Industry of the Russian Federation (Protocol No. 4 of June 13, 1996). A total of 213 children with central and peripheral retinal abiotrophy, partial atrophy of the optic nerve, refraction and dysbinocular amblyopia, and healthy children were examined.

[Comparative analysis of metabolites of Candida albicans and other clinically important fungi using gas chromatography].

Qualitative and quantitative compositions of metabolites of the fungi belonging to the genera Candida, Cryptococcus, Geotrichum, Aspergillus, Penicillium, Fusarlum, Actinomyces, Sporotrichum and Alternaria were studied. It was shown that the composition of carbohydrates, alcohols, volatile and nonvolatile fatty acids and amines after the fungi cultivation was specific of every genus. The in vitro investigation of the entire spectra of the metabolites such as monosugars, alcohols, volatile and nonvolatile acids and amines for the determination of the markers specific of the genus Candida demonstrated that for the indication of C.

[Analysis of higher fatty acids of fungi of the genus Candida using gas chromatography].

The fatty acid composition of the cell biomass of 136 strains of 9 species belonging to the genus Candida was investigated. The cell walls were found to contain the following fatty acids: myristic, hexadecenoic, palmitic, heptadecanoic, linoleic, linolenic, stearic, lignocerinic and oleic. Acids with 18 carbon atoms in the chain i.

[The identification of fungi by their cellular monosaccharides using gas-liquid chromatography].

The qualitative composition and percent ratio of monosugars in the cell biomass of 101 strains of 5 Candida species and 7 strains of Torulopsis species were determined. It was shown that the major carbohydrate components of the cell biomass of all the Candida species were arabinitol, mannose, fructose, galactose, glucose, sugar alcohol (mannitol) and myoisonitol. C.

[The individual characteristics of the nociceptive sensitivity of Wistar rats correlated with the content of steroid hormones in the blood plasma].

In male rats of Wistar strain individual nociceptive sensitivity properties were studied in correlation with steroid hormones level in the plasma. Seven groups of experimental animals were observed remarkable for dynamics of nociceptive sensitivity. Repeatedly applied test painful stimuli caused reliable changes of corticosterone and testosterone level in the plasma.

[Individual characteristics of the nociceptive sensitivity of rats during the formation of a negative emotional reaction].

Changes in dynamics of nociceptive sensitivity in male rats of Wistar strain were studied during formation of negative emotional reaction. The procedure of blood's taking from the tail after its tip's amputation was used as negative emotional factor. The animals were divided into six groups by the criterion of individual properties of nociceptive sensitivity dynamics.

[Dynamics of nociceptive sensitivity and blood levels of steroid hormones in Wistar rats].

Changes in nociceptive sensitivity and the level of steroid hormones (corticosterone and testosterone) in the plasma of male Wistar rats were studied in repeatedly applied painful stimuli. According to the changes in nociceptive sensitivity the animals were divided into 6 groups. A reliable corticosterone increment and testosterone decrement in the plasma were caused by repeatedly applied painful stimuli.

[Characteristics of the nociceptive sensitivity of Wistar rats].

Changes in sensitivity to repeated nociceptive stimuli permitted to divide male Wistar rats into 6 groups using the observed differences in nociceptive sensitivity dynamics as reliable indices.