Publications by authors named "Rogan Corbridge"
Background: Pharyngeal pouches are generally treated with surgery, via either an endoscopic or an external approach. Large pouches extending to the mediastinum carry an increased risk of post-operative mediastinitis in the event of a leak following external approach surgery, and may not always be amenable to endoscopic stapling.
Methods: Transcervical stapling is a newly described technique that uses the endoluminal stapling approach but in which the diverticuloscope is inserted into the pharynx via a neck incision.
Background: Ultrasound-guided fine-needle aspiration cytology is the gold standard for investigating thyroid nodules. Stratifying the Thy3 thyroid nodule risk of malignancy is essential for clinical decision-making. According to the Royal College of Pathologists Guidance (2016), the rate of malignancy for Thy3a is 5-15% and for Thy3f 15-30%.
View Article and Find Full Text PDFA 53-year-old woman presented with right-sided otalgia radiating to the temporal region, angle of the mandible and upper neck. Otoscopy was unremarkable on examination and there were no signs of otitis externa. MRI revealed an infiltrative soft tissue mass to the right lateral aspect of the clivus.
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- - The study aimed to assess hearing loss prevalence among elderly inpatients, evaluate the feasibility of a simple screening method, and report on subsequent hearing aid provision.
- - Out of 51 patients screened, 41% reported hearing difficulties, with 31% failing a whisper test, leading to 73% being referred for further audiological assessment.
- - Ultimately, 33% of those assessed had aidable hearing loss, and 22% received hearing aids, indicating that a straightforward two-step screening effectively identifies unmet hearing needs in this population.
Pharyngeal pouches are common, particularly in the elderly population, in whom they can cause significant morbidity. The advanced age of many patients and existing comorbidities mean that in some cases neither open nor endoscopic pouch stapling is possible. We present a technique of combined open and endoscopic pharyngeal pouch surgery, which may be used when other therapeutic options are limited.
View Article and Find Full Text PDFBackground: Hypoxia is an important mechanism of treatment resistance in head and neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that regulate multiple mRNAs and are frequently dysregulated in cancer. The authors have investigated the role of 3 microRNAs, including the hypoxia-induced hsa-miR-210, as potential markers of hypoxia or prognosis.
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- The study investigates survival outcomes and complications following surgical treatment of advanced neck disease (N2c/N3) in head and neck squamous cell carcinoma patients.
- A review of 39 patients at the Oxford Radcliffe Infirmary revealed a 63% and 52% overall survival rate at 2 and 5 years, respectively, despite the challenging prognosis traditionally associated with advanced neck disease.
- The findings suggest that combining surgery with postoperative radiotherapy can lead to favorable outcomes, challenging the shift away from surgery for advanced cases and supporting the idea that these patients can achieve reasonable prognoses with proper treatment.
Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g.
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- The study investigates how hypoxia, particularly through the HIF pathway, influences tumor growth in head and neck squamous cell carcinoma (HNSCC), focusing on the expression of HIF-1alpha and HIF-2alpha.
- The results show that high levels of HIF-1alpha are linked to worse survival outcomes, while some tumors with both HIF-1alpha and HIF-2alpha expression present additional poor prognosis factors.
- Anemia does not seem to directly affect HIF-alpha expression in tumors, implying that other intrinsic tumor factors may play a more significant role in regulating HIF-alpha levels and outcomes.
Article Synopsis
- The study highlights a growing need for effective emergency airway management in ENT wards due to increased cross-cover of specialities and direct patient triaging at night.
- Researchers conducted a survey of 103 English hospitals, finding that only 18% had a portable airway box and just 28% provided airway management training.
- The findings indicate inadequate emergency airway resources and training, leading to recommendations for a standardized airway box and minimum equipment requirements.
Article Synopsis
- The study investigates the role of erythropoietin and its receptor in head and neck squamous cell carcinoma (HNSCC), noting a link to poor survival rates.
- Erythropoietin was found in 95% and its receptor in 99% of HNSCC cases, with some correlation to hypoxia markers but no impact on patient survival or hemoglobin levels.
- The results suggest that while the HIF pathway influences erythropoietin expression at the mRNA level, anemia doesn't significantly affect its expression in tumors, indicating other factors may influence tumor behavior.