Computational prediction of multiple antigen epitopes.

Motivation: Identifying antigen epitopes is essential in medical applications, such as immunodiagnostic reagent discovery, vaccine design, and drug development. Computational approaches can complement low-throughput, time-consuming, and costly experimental determination of epitopes. Currently available prediction methods, however, have moderate success predicting epitopes, which limits their applicability.

Computational Prediction of Multiple Antigen Epitopes.

Motivation: Identifying antigen epitopes is essential in medical applications, such as immunodiagnostic reagent discovery, vaccine design, and drug development. Computational approaches can complement low-throughput, time-consuming, and costly experimental determination of epitopes. Currently available prediction methods, however, have moderate success predicting epitopes, which limits their applicability.

How to interpret and apply the results of indirect calorimetry studies: A case-based tutorial.

Evidence is growing that the individual adjustment of energy targets guided by indirect calorimetry (IC) can improve outcome. With the development of a new generation of devices that are easier to use and rapid, it appears important to share knowledge and expertise that may be used to individualize nutrition care. Despite the focus of this tutorial being on one contemporary device, the principles of IC apply across existing devices and can assist tailoring the nutrition prescription and in assessing response to nutrition therapy.

Relationship between kalemia and intensive care unit admission or death in hospitalized COVID-19 patients: A cohort study.

Background: SARS-CoV-2 uses Angiotensin-Converting Enzyme 2 as a viral gateway to the cell and could interact with the renin-angiotensin-aldosterone system. Other studies have shown kalemia abnormalities in patients with severe forms of coronavirus disease 2019. Our goal was to assess the prognosis value of kalemia within ten days of symptom offset in the COVID-19 hospitalized population.

[Actual use of direct oral anticoagulants in venous thromboembolic disease].

Direct oral anticoagulants recently became the first-line choice for anticoagulation in venous thromboembolic disease. Many studies have shown its non-inferiority regarding the risk of thromboembolic recurrence compared to anti-vitamin K without increasing the risk of bleeding in the general population. However, specific populations such as patients with cancer, patients with kidney failure, patients with constitutional thrombophilia, elderly patients, or patients with extreme weight are at risk of intolerance to the use of direct oral anticoagulants.

Curative anticoagulation prevents endothelial lesion in COVID-19 patients.

Background: Coronavirus disease-2019 (COVID-19) has been associated with cardiovascular complications and coagulation disorders.

Objectives: To explore the coagulopathy and endothelial dysfunction in COVID-19 patients.

Methods: The study analyzed clinical and biological profiles of patients with suspected COVID-19 infection at admission, including hemostasis tests and quantification of circulating endothelial cells (CECs).

Drift as constitutive: conclusions from a formal reconstruction of population genetics.

This article elaborates on McShea and Brandon's idea that drift is unlike the rest of the evolutionary factors because it is constitutive rather than imposed on the evolutionary process. I show that the way they spelled out this idea renders it inadequate and is the reason why it received some (good) objections. I propose a different way in which their point could be understood, that rests on two general distinctions.

Optimality Models and the Propensity Interpretation of Fitness.

The propensity account of fitness intends to solve the classical tautologicity issue by identifying fitness with a disposition, the ability to survive and reproduce. As proponents recognized early on, this account requires operational independence from actual reproductive success to avoid circularity and vacuousness charges. They suggested that operational independence is achieved by measuring fitness values through optimality models.

Correction to: Theoricity, observation and homology: a response to Pearson.

Due to an unfortunate turn of events, the family name of the first author was erroneously published as 'RoffÕ' in the original publication (PDF). The correct representation of the first author's family name is listed above and below.

Theoricity, observation and homology: a response to Pearson.

An interesting metatheoretical controversy took place during the 1980's and 1990's between pattern and phylogenetic cladists. What was always at stake in the discussion was not how work in systematics should be carried out, but rather how this practice should be metatheoretically interpreted. In this article, we criticize Pearson's account of the metatheoretical factors at play in this discussion.