Expression of Low Affinity Nerve Growth Factor Receptor p75 in Classic Bladder Exstrophy.

Successful primary closure of classic bladder exstrophy (BE) is crucial for development of bladder capacity and voided continence. It is universally agreed that an intensive pain management including the use of caudal epidural anesthesia is an essential cornerstone for the outcome of this complex surgery. Whether and to what extent pain is caused by structural or functional changes is not yet known.

Zinner syndrome and infertility─a literature review based on a clinical case.

Zinner syndrome (ZS) is a rare congenital malformation associated with seminal vesicle cysts, ejaculatory duct obstruction, and ipsilateral renal agenesis. The main treatment focus so far has been on symptomatic patients. Therefore, surgery has been reserved for these patients, and surgical treatment is mainly aimed at pain relief.

Recent Trends in the Management of Bladder Exstrophy: The Gordian Knot Has Not Yet Been Cut.

Although enormous effort has been made to further improve the operative techniques worldwide, the management of bladder exstrophy (BE) remains one of the most significant challenges in pediatric urology. Today it is universally agreed that successful and gentle initial bladder closure is decisive for favorable long-term outcome with regard to bladder capacity, renal function and continence. Due to a number of reasons, including a lack of comparable multicenter studies, a range of concepts is currently used to achieve successful primary closure.

Male infertility: assessment of juvenile testicular dysfunction and risk for malignancy in cryptorchid boys based on resin section evaluation.

Infertility is sometimes more a man's problem than a woman's, failure of one or both of the testes to descend (cryptorchidism) being the most frequent genital malformation in boys. Untreated, the undescended testis impairs germ cell development and significantly reduces adult fertility. A-dark spermatogonia are the stem cells for all future spermatozoa, and their depletion can be reliably estimated in resin semithin sections.

Persistent histological changes in the exstrophic bladder after primary closure-a cause for concern?

Purpose: We investigated bladder biopsies from patients with classic bladder exstrophy for the histological features and discuss the potential clinical significance of the findings.

Materials And Methods: Bladder tissues were collected from patients with bladder exstrophy between 2004 and 2011. These specimens were obtained at primary bladder closure (group 1, 29 patients), during secondary reconstructive procedures (group 2, 27) or during cystectomy for failed reconstruction (group 3, 15).

Expression and potential clinical significance of urothelial cytodifferentiation markers in the exstrophic bladder.

Purpose: We characterize the urothelium from patients with classic bladder exstrophy-epispadias complex for the expression of proteins associated with urothelial differentiation, and discuss a potential impact of urothelial phenotype on the structural and functional properties of the bladder template following bladder closure.

Materials And Methods: From 2005 to 2010 bladder biopsies from 32 infants with bladder exstrophy-epispadias complex obtained at primary bladder closure were collected. After histological assessment immunochemistry was used to investigate the expression of uroplakin IIIa, cytokeratin differentiation restricted antigens CK13 and CK20, and tight junction protein claudin 4.

Psychosocial and psychosexual development in childhood and adolescence within the exstrophy-epispadias complex.

Purpose: We report the psychosocial and psychosexual development of children and adolescents with the exstrophy-epispadias complex (EEC) after complete functional repair using the Erlangen single stage technique.

Materials And Methods: In a long-term retrospective followup of an average of 11.1 years 100 patients with EEC (76 boys and 24 girls, mean age 14.

SF-36 health status of workers compensation cases with spinal disorders.

Background Context: Poorer outcomes of treatment are reported in patients with spinal disorders who receive workers compensation. The reason for their suboptimal outcomes is unclear. No study has examined the relationship between workers compensation and the Short Form Health Survey (SF-36) health status of patients with spinal disorders.

Do worker's compensation patients with neck pain have lower SF-36 scores?

Poorer outcomes of treatment are reported in patients with spinal disorders who receive worker's compensation. The reason for their suboptimal outcomes is unclear. No study has examined the relationship between worker's compensation and SF-36 health status of patients with neck pain.

Transforaminal interbody fusion versus anterior-posterior interbody fusion of the lumbar spine: a financial analysis.

Lumbar interbody fusion can be performed anteriorly or posteriorly. An anterior approach generally requires an access surgeon and often is combined with a posterior fusion. A traditional posterior interbody fusion can destabilize the spinal motion segment and requires neural retraction.

Isolated subaxial cervical spine stenosis in achondroplasia.

Although isolated subaxial cervical spine stenosis in achondroplasia is less common than narrowing at the foramen magnum, thoracolumbar junction, or lumbar spine, it should be recognized as a distinct entity. These congenital changes usually become symptomatic when combined with degenerative changes in early adult life. Yearly monitoring of adult achondroplastic patients for signs and symptoms of cervical myelopathy or radiculopathy is recommended.

Multiple components of split-dose repair in plateau-phase mammalian cells: a new challenge for phenomenological modelers.

Split-dose experiments using starved plateau-phase Chinese hamster ovary cells have been used to investigate the kinetics of repair, expressed in terms of enhancement of reproductive survival. The results show two distinct components of repair, one having a characteristic time of just over 1 h for the removal of a lesion, the other, about 18 h. The rate at which each component removes damage and the fraction of the total damage that each removes appear to be independent of the initial amount of damage produced, i.

Analyzing the role of biochemical processes in determining response to ionizing radiations.

The interaction of biochemical processes and radiation damage appears to play a major role in determining long-term biological effects. It is responsible for both the removal of radiation-induced alterations in macromolecules and for the time-dependent changes in survival of irradiated cells. Restoration of macromolecules by such means as the rejoining of strand breaks in DNA suggests a variety of possible mechanisms which could lead to the observed enhancement of cell survival.

Guide-wire perforation during bougienage and tube positioning. Report on three cases and technical improvement.

Report on three perforations during bougienage or tube insertion due to sharp bending of the guide wire. A new, fully flexible guide wire is described, which might obviate this unnecessary complication.

Dose-rate evidence for two kinds of radiation damage in stationary-phase mammalian cells.

Survival based on colony formation was measured for starved plateau-phase Chinese hamster ovary (CHO) cells exposed to 250 kVp X rays at dose rates of 0.0031, 0.025, 0.

Primary malignant melanoma of the oesophagus.

Primary malignant melanoma of the oesophagus is a rare tumour, whereas metastatic disease originating from melanomas is occasionally encountered in the upper GI-tract. Two cases of endoscopically diagnosed primary esophageal melanomas are presented which were treated by surgery and radiotherapy combined with immunostimulation, respectively.

New methods in gastroenterology.

Major advances in gastroenterology are due in part to the rapid development of fiberendoscopes. Originally intended to improve gastroenterological diagnostics, the field of application was broadened by a variety of therapeutic procedures which now concur with the corresponding surgical approach. Endoscopic electro- and photocoagulation has considerably improved the outcome of acute gastrointestinal hemorrhage: endoscopic polypectomy is the procedure of choice today in benign and occasionally in malignant bowel tumors.