Publications by authors named "Roel R I van Reij"

Article Synopsis
  • - The study investigates the genetic factors contributing to chronic post-surgical pain (CPSP) by analyzing data from 1,350 individuals who underwent various types of surgery, and highlights a significant genetic component, estimating a 39% heritability for CPSP through meta-analysis.
  • - Researchers identified 77 key genetic variations (SNPs) linked to CPSP and noted that most of these are associated with immune system genes, especially those related to B and T cells.
  • - Animal studies showed that mice without T and B cells experienced worsened pain after surgery, which could be mitigated by transferring B cells, suggesting that the adaptive immune system plays a crucial protective role against CPSP.
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Chronic post-surgical pain affects a large proportion of people undergoing surgery, delaying recovery time and worsening quality of life. Although many environmental variables have been established as risk factors, less is known about genetic risk. To uncover genetic risk factors we performed genome-wide association studies in post-surgical cohorts of five surgery types- hysterectomy, mastectomy, abdominal, hernia, and knee- totaling 1350 individuals.

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Dopamine (DA) is an important modulator in nociception and analgesia. Spinal DA receptors are involved in descending modulation of the nociceptive transmission. Genetic variations within DA neurotransmission have been associated with altered pain sensitivity and development of chronic pain syndromes.

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Chronic postsurgical pain (CPSP) is a debilitating chronic pain condition that has a substantial effect on quality of life. CPSP shows considerable clinical overlap with different chronic peripheral pain syndromes, suggesting a shared aetiology. This study aims to assess the genetic overlap between different chronic pain syndromes and CPSP, providing relevant biological context for potential chronic pain markers of CPSP.

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Chronic post-surgical pain (CPSP) is a debilitating condition affecting 10-50% of surgical patients. The current treatment strategy for CPSP is not optimal, and the identification of genetic variation in surgical patients might help to improve prediction and treatment of CPSP. The neurotransmitter dopamine (DA) has been associated with several chronic pain disorders.

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Background: Chronic post-surgical pain (CPSP) is a serious problem. Clinical and psychological variables have not been able to explain all observed variance in prevalence and severity of CPSP. The first objective is to determine the association between genetic polymorphisms and the prevalence of CPSP after hysterectomy.

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